Drug Signature

Direct Drug targets

The set of genes (derived based on the set of proteins) which are indicated in DrugBank either as drug target, drug transporter or drug metabolizing enzyme is defined as a direct drug targets. In addition, we use Pubchem Bioassay repository. Reference to Pubchem Bioassay repository means that the drug was tested in HTS assay and was found to inhibit the activity of the tested protein.

Indirect Drug targets

Indirect drug targets, along with direct drug targets, include proteins which interact with the direct drug targets based on the records of IntAct database of protein-protein interactions.

drug_signature

DRUGSURV: Drug Signature model


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