Polypharmacology report

Abreviations used here:

  • kA:The number of active compounds known to target the pattern
  • KA:The total number of active compounds(IC50 < 10-6)
  • kB:The number of inactive compounds known to target the pattern
  • KB:The total number of inactive compounds(IC50 >10-6)
  • Odds Ratio: (kA/kB) / ( (KA-kA) / (KB - kB) )

Individual statistics for TLR4 in the assay 686971:

  • kA: 60
  • KA: 7342
  • kB: 278
  • KB: 227332
  • Odds Ratio: 6.7

Table 1. Poly-pharmacological protein patterns (with TLR4) enriched among Active molecules

# Target Duplet P-value
FDR adjusted
Odds Ratio kA KA kB KB Polypharmacology triplets View
Compounds
details
View Pattern Profile
1 TLR4 and SMAD3 1.04e-21 111.7 18 7342 5 227332 Polypharmacology Molecules Target Profile
2 TLR4 and JAK2 6.13e-31 101.0 26 7342 8 227332 Polypharmacology Molecules Target Profile
3 TLR4 and TNF 2.07e-15 100.8 13 7342 4 227332 Polypharmacology Molecules Target Profile
4 TLR4 and HIF1A 3.99e-21 93.1 18 7342 6 227332 Polypharmacology Molecules Target Profile
5 TLR4 and ATXN2 7.78e-27 89.3 23 7342 8 227332 Polypharmacology Molecules Target Profile
6 TLR4 and PAX8 2.67e-23 88.7 20 7342 7 227332 Polypharmacology Molecules Target Profile
7 TLR4 and IDH1 2.06e-52 87.6 45 7342 16 227332 Polypharmacology Molecules Target Profile
8 TLR4 and NPSR1 2.64e-26 79.4 23 7342 9 227332 Polypharmacology Molecules Target Profile
9 TLR4 and EPAS1 2.22e-36 76.5 32 7342 13 227332 Polypharmacology Molecules Target Profile
10 TLR4 and NOD2 2.13e-14 67.2 13 7342 6 227332 Polypharmacology Molecules Target Profile
11 TLR4 and ADRB2 1.20e-19 62.1 18 7342 9 227332 Polypharmacology Molecules Target Profile
12 TLR4 and VDR 1.03e-22 59.3 21 7342 11 227332 Polypharmacology Molecules Target Profile
13 TLR4 and NOD1 2.46e-18 58.6 17 7342 9 227332 Polypharmacology Molecules Target Profile
14 TLR4 and CXCR6 3.77e-16 58.2 15 7342 8 227332 Polypharmacology Molecules Target Profile
15 TLR4 and CFTR 7.82e-29 55.9 27 7342 15 227332 Polypharmacology Molecules Target Profile
16 TLR4 and NPY1R 1.83e-14 48.3 14 7342 9 227332 Polypharmacology Molecules Target Profile
17 TLR4 and MITF 9.35e-38 46.1 37 7342 25 227332 Polypharmacology Molecules Target Profile
18 TLR4 and CCR6 1.36e-15 38.2 16 7342 13 227332 Polypharmacology Molecules Target Profile
19 TLR4 and NR5A1 1.59e-12 36.7 13 7342 11 227332 Polypharmacology Molecules Target Profile
20 TLR4 and S1PR4 6.07e-26 36.5 27 7342 23 227332 Polypharmacology Molecules Target Profile
21 TLR4 and NPBWR1 2.80e-15 35.5 16 7342 14 227332 Polypharmacology Molecules Target Profile
22 TLR4 and S1PR1 4.14e-17 34.9 18 7342 16 227332 Polypharmacology Molecules Target Profile
23 TLR4 and TNFRSF10B 5.52e-15 33.1 16 7342 15 227332 Polypharmacology Molecules Target Profile
24 TLR4 and NFE2L2 8.17e-17 32.9 18 7342 17 227332 Polypharmacology Molecules Target Profile
25 TLR4 and IL1B 3.21e-45 30.0 50 7342 52 227332 Polypharmacology Molecules Target Profile
26 TLR4 and KCNJ1 1.62e-15 21.8 19 7342 27 227332 Polypharmacology Molecules Target Profile
27 TLR4 and ALDH1A1 2.18e-17 20.1 22 7342 34 227332 Polypharmacology Molecules Target Profile
28 TLR4 and HTT 8.43e-16 20.0 20 7342 31 227332 Polypharmacology Molecules Target Profile
29 TLR4 and STAT1 3.25e-14 20.0 18 7342 28 227332 Polypharmacology Molecules Target Profile
30 TLR4 and KCNQ1 4.07e-13 16.4 18 7342 34 227332 Polypharmacology Molecules Target Profile
31 TLR4 and TDP1 6.14e-39 15.7 55 7342 109 227332 Polypharmacology Molecules Target Profile
32 TLR4 and HSPA1A 1.14e-14 341.1 11 7342 1 227332 Polypharmacology Molecules Target Profile
33 TLR4 and PRNP 8.71e-12 279.0 9 7342 1 227332 Polypharmacology Molecules Target Profile
34 TLR4 and XBP1 1.63e-07 185.9 6 7342 1 227332 Polypharmacology Molecules Target Profile
35 TLR4 and SELE 1.71e-10 93.0 9 7342 3 227332 Polypharmacology Molecules Target Profile
36 TLR4 and NCOA1 6.17e-07 93.0 6 7342 2 227332 Polypharmacology Molecules Target Profile
37 TLR4 and NLRP3 1.37e-05 77.5 5 7342 2 227332 Polypharmacology Molecules Target Profile
38 TLR4 and GALR3 3.35e-12 68.2 11 7342 5 227332 Polypharmacology Molecules Target Profile
39 TLR4 and HPGD 3.36e-09 46.5 9 7342 6 227332 Polypharmacology Molecules Target Profile
40 TLR4 and NR5A2 3.36e-09 46.5 9 7342 6 227332 Polypharmacology Molecules Target Profile
41 TLR4 and TSHR 7.32e-09 39.9 9 7342 7 227332 Polypharmacology Molecules Target Profile
42 TLR4 and SLC12A5 7.51e-05 38.7 5 7342 4 227332 Polypharmacology Molecules Target Profile
43 TLR4 and TP53 8.81e-06 37.2 6 7342 5 227332 Polypharmacology Molecules Target Profile
44 TLR4 and HTR1A 8.81e-06 37.2 6 7342 5 227332 Polypharmacology Molecules Target Profile
45 TLR4 and PTGER2 1.25e-07 35.4 8 7342 7 227332 Polypharmacology Molecules Target Profile
46 TLR4 and HSP90AA1 1.98e-06 31.0 7 7342 7 227332 Polypharmacology Molecules Target Profile
47 TLR4 and NPY2R 9.09e-08 25.4 9 7342 11 227332 Polypharmacology Molecules Target Profile
48 TLR4 and MC4R 7.95e-10 21.9 12 7342 17 227332 Polypharmacology Molecules Target Profile