Polypharmacology report

Abreviations used here:

  • kA:The number of active compounds known to target the pattern
  • KA:The total number of active compounds(IC50 < 10-6)
  • kB:The number of inactive compounds known to target the pattern
  • KB:The total number of inactive compounds(IC50 >10-6)
  • Odds Ratio: (kA/kB) / ( (KA-kA) / (KB - kB) )

Individual statistics for MDM2 in the assay 686971:

  • kA: 31
  • KA: 7342
  • kB: 182
  • KB: 227332
  • Odds Ratio: 5.3

Table 1. Poly-pharmacological protein patterns (with MDM2) enriched among Active molecules

# Target Duplet P-value
FDR adjusted
Odds Ratio kA KA kB KB Polypharmacology triplets View
Compounds
details
View Pattern Profile
1 MDM2 and PAX8 1.79e-12 155.0 10 7342 2 227332 Polypharmacology Molecules Target Profile
2 MDM2 and IDH1 4.41e-30 149.1 24 7342 5 227332 Polypharmacology Molecules Target Profile
3 MDM2 and NR2F2 1.10e-09 124.0 8 7342 2 227332 Polypharmacology Molecules Target Profile
4 MDM2 and NCOA2 2.66e-08 108.5 7 7342 2 227332 Polypharmacology Molecules Target Profile
5 MDM2 and XBP1 2.45e-11 77.5 10 7342 4 227332 Polypharmacology Molecules Target Profile
6 MDM2 and DRD3 1.27e-23 72.5 21 7342 9 227332 Polypharmacology Molecules Target Profile
7 MDM2 and SELE 8.40e-08 72.3 7 7342 3 227332 Polypharmacology Molecules Target Profile
8 MDM2 and WEE1 8.40e-08 72.3 7 7342 3 227332 Polypharmacology Molecules Target Profile
9 MDM2 and TNF 5.78e-14 57.6 13 7342 7 227332 Polypharmacology Molecules Target Profile
10 MDM2 and CFTR 2.10e-21 56.4 20 7342 11 227332 Polypharmacology Molecules Target Profile
11 MDM2 and NOD1 1.54e-17 48.0 17 7342 11 227332 Polypharmacology Molecules Target Profile
12 MDM2 and MITF 1.63e-21 46.6 21 7342 14 227332 Polypharmacology Molecules Target Profile
13 MDM2 and EPAS1 5.18e-15 42.3 15 7342 11 227332 Polypharmacology Molecules Target Profile
14 MDM2 and IL1B 8.92e-25 40.9 25 7342 19 227332 Polypharmacology Molecules Target Profile
15 MDM2 and JAK2 7.32e-09 39.9 9 7342 7 227332 Polypharmacology Molecules Target Profile
16 MDM2 and GMNN 1.56e-23 39.2 24 7342 19 227332 Polypharmacology Molecules Target Profile
17 MDM2 and HNF4A 1.49e-08 34.9 9 7342 8 227332 Polypharmacology Molecules Target Profile
18 MDM2 and NPSR1 1.98e-06 31.0 7 7342 7 227332 Polypharmacology Molecules Target Profile
19 MDM2 and HTT 7.45e-07 24.8 8 7342 10 227332 Polypharmacology Molecules Target Profile
20 MDM2 and VDR 2.49e-07 21.5 9 7342 13 227332 Polypharmacology Molecules Target Profile
21 MDM2 and STAT1 2.49e-07 21.5 9 7342 13 227332 Polypharmacology Molecules Target Profile
22 MDM2 and MAPT 2.68e-13 19.5 17 7342 27 227332 Polypharmacology Molecules Target Profile
23 MDM2 and TDP1 5.84e-23 18.7 30 7342 50 227332 Polypharmacology Molecules Target Profile
24 MDM2 and PRNP 6.17e-07 93.0 6 7342 2 227332 Polypharmacology Molecules Target Profile
25 MDM2 and NPBWR1 1.37e-05 77.5 5 7342 2 227332 Polypharmacology Molecules Target Profile
26 MDM2 and GPR55 7.51e-05 38.7 5 7342 4 227332 Polypharmacology Molecules Target Profile
27 MDM2 and TAAR1 0.00014 31.0 5 7342 5 227332 Polypharmacology Molecules Target Profile
28 MDM2 and SMARCA2 0.00014 31.0 5 7342 5 227332 Polypharmacology Molecules Target Profile
29 MDM2 and GPR183 2.98e-05 26.6 6 7342 7 227332 Polypharmacology Molecules Target Profile