Polypharmacology report
- Pubchem Assay ID: 686971
- Title: qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line
- Target: MDM2
Abreviations used here:
- kA:The number of active compounds known to target the pattern
- KA:The total number of active compounds(IC50 < 10-6)
- kB:The number of inactive compounds known to target the pattern
- KB:The total number of inactive compounds(IC50 >10-6)
- Odds Ratio: (kA/kB) / ( (KA-kA) / (KB - kB) )
Individual statistics for MDM2 in the assay 686971:
- kA: 31
- KA: 7342
- kB: 182
- KB: 227332
- Odds Ratio: 5.3
Table 1. Poly-pharmacological protein patterns (with MDM2) enriched among Active molecules
# | Target Duplet | P-value FDR adjusted |
Odds Ratio | kA | KA | kB | KB | Polypharmacology triplets | View Compounds details |
View Pattern Profile |
1 | MDM2 and PAX8 | 1.79e-12 | 155.0 | 10 | 7342 | 2 | 227332 | Polypharmacology | Molecules | Target Profile |
2 | MDM2 and IDH1 | 4.41e-30 | 149.1 | 24 | 7342 | 5 | 227332 | Polypharmacology | Molecules | Target Profile |
3 | MDM2 and NR2F2 | 1.10e-09 | 124.0 | 8 | 7342 | 2 | 227332 | Polypharmacology | Molecules | Target Profile |
4 | MDM2 and NCOA2 | 2.66e-08 | 108.5 | 7 | 7342 | 2 | 227332 | Polypharmacology | Molecules | Target Profile |
5 | MDM2 and XBP1 | 2.45e-11 | 77.5 | 10 | 7342 | 4 | 227332 | Polypharmacology | Molecules | Target Profile |
6 | MDM2 and DRD3 | 1.27e-23 | 72.5 | 21 | 7342 | 9 | 227332 | Polypharmacology | Molecules | Target Profile |
7 | MDM2 and WEE1 | 8.40e-08 | 72.3 | 7 | 7342 | 3 | 227332 | Polypharmacology | Molecules | Target Profile |
8 | MDM2 and SELE | 8.40e-08 | 72.3 | 7 | 7342 | 3 | 227332 | Polypharmacology | Molecules | Target Profile |
9 | MDM2 and TNF | 5.78e-14 | 57.6 | 13 | 7342 | 7 | 227332 | Polypharmacology | Molecules | Target Profile |
10 | MDM2 and CFTR | 2.10e-21 | 56.4 | 20 | 7342 | 11 | 227332 | Polypharmacology | Molecules | Target Profile |
11 | MDM2 and NOD1 | 1.54e-17 | 48.0 | 17 | 7342 | 11 | 227332 | Polypharmacology | Molecules | Target Profile |
12 | MDM2 and MITF | 1.63e-21 | 46.6 | 21 | 7342 | 14 | 227332 | Polypharmacology | Molecules | Target Profile |
13 | MDM2 and EPAS1 | 5.18e-15 | 42.3 | 15 | 7342 | 11 | 227332 | Polypharmacology | Molecules | Target Profile |
14 | MDM2 and IL1B | 8.92e-25 | 40.9 | 25 | 7342 | 19 | 227332 | Polypharmacology | Molecules | Target Profile |
15 | MDM2 and JAK2 | 7.32e-09 | 39.9 | 9 | 7342 | 7 | 227332 | Polypharmacology | Molecules | Target Profile |
16 | MDM2 and GMNN | 1.56e-23 | 39.2 | 24 | 7342 | 19 | 227332 | Polypharmacology | Molecules | Target Profile |
17 | MDM2 and HNF4A | 1.49e-08 | 34.9 | 9 | 7342 | 8 | 227332 | Polypharmacology | Molecules | Target Profile |
18 | MDM2 and NPSR1 | 1.98e-06 | 31.0 | 7 | 7342 | 7 | 227332 | Polypharmacology | Molecules | Target Profile |
19 | MDM2 and HTT | 7.45e-07 | 24.8 | 8 | 7342 | 10 | 227332 | Polypharmacology | Molecules | Target Profile |
20 | MDM2 and VDR | 2.49e-07 | 21.5 | 9 | 7342 | 13 | 227332 | Polypharmacology | Molecules | Target Profile |
21 | MDM2 and STAT1 | 2.49e-07 | 21.5 | 9 | 7342 | 13 | 227332 | Polypharmacology | Molecules | Target Profile |
22 | MDM2 and MAPT | 2.68e-13 | 19.5 | 17 | 7342 | 27 | 227332 | Polypharmacology | Molecules | Target Profile |
23 | MDM2 and TDP1 | 5.84e-23 | 18.7 | 30 | 7342 | 50 | 227332 | Polypharmacology | Molecules | Target Profile |
24 | MDM2 and PRNP | 6.17e-07 | 93.0 | 6 | 7342 | 2 | 227332 | Polypharmacology | Molecules | Target Profile |
25 | MDM2 and NPBWR1 | 1.37e-05 | 77.5 | 5 | 7342 | 2 | 227332 | Polypharmacology | Molecules | Target Profile |
26 | MDM2 and GPR55 | 7.51e-05 | 38.7 | 5 | 7342 | 4 | 227332 | Polypharmacology | Molecules | Target Profile |
27 | MDM2 and SMARCA2 | 0.00014 | 31.0 | 5 | 7342 | 5 | 227332 | Polypharmacology | Molecules | Target Profile |
28 | MDM2 and TAAR1 | 0.00014 | 31.0 | 5 | 7342 | 5 | 227332 | Polypharmacology | Molecules | Target Profile |
29 | MDM2 and GPR183 | 2.98e-05 | 26.6 | 6 | 7342 | 7 | 227332 | Polypharmacology | Molecules | Target Profile |