Polypharmacology report

Abreviations used here:

  • kA:The number of active compounds known to target the pattern
  • KA:The total number of active compounds(IC50 < 10-6)
  • kB:The number of inactive compounds known to target the pattern
  • KB:The total number of inactive compounds(IC50 >10-6)
  • Odds Ratio: (kA/kB) / ( (KA-kA) / (KB - kB) )

Individual statistics for HNF4A in the assay 686971:

  • kA: 483
  • KA: 7342
  • kB: 1258
  • KB: 227332
  • Odds Ratio: 12.7

Table 1. Poly-pharmacological protein patterns (with HNF4A) enriched among Active molecules

# Target Duplet P-value
FDR adjusted
Odds Ratio kA KA kB KB Polypharmacology triplets View
Compounds
details
View Pattern Profile
1 HNF4A and TNFRSF10B 3.33e-162 129.0 131 7342 32 227332 Polypharmacology Molecules Target Profile
2 HNF4A and IDH1 0. 110.1 323 7342 95 227332 Polypharmacology Molecules Target Profile
3 HNF4A and MITF 3.88e-288 86.9 247 7342 91 227332 Polypharmacology Molecules Target Profile
4 HNF4A and PAX8 7.92e-177 79.8 154 7342 61 227332 Polypharmacology Molecules Target Profile
5 HNF4A and EPAS1 0. 67.7 306 7342 146 227332 Polypharmacology Molecules Target Profile
6 HNF4A and CXCR6 2.72e-151 63.1 138 7342 69 227332 Polypharmacology Molecules Target Profile
7 HNF4A and HIF1A 1.21e-193 62.4 177 7342 90 227332 Polypharmacology Molecules Target Profile
8 HNF4A and CFTR 1.95e-291 58.6 270 7342 148 227332 Polypharmacology Molecules Target Profile
9 HNF4A and ATXN2 3.49e-278 57.3 259 7342 145 227332 Polypharmacology Molecules Target Profile
10 HNF4A and CCR6 9.65e-148 56.5 138 7342 77 227332 Polypharmacology Molecules Target Profile
11 HNF4A and SMAD3 4.06e-244 55.4 229 7342 132 227332 Polypharmacology Molecules Target Profile
12 HNF4A and DRD3 5.38e-258 53.5 244 7342 146 227332 Polypharmacology Molecules Target Profile
13 HNF4A and CHRM4 2.34e-105 48.5 102 7342 66 227332 Polypharmacology Molecules Target Profile
14 HNF4A and ADRB2 5.13e-106 46.0 104 7342 71 227332 Polypharmacology Molecules Target Profile
15 HNF4A and NFE2L2 1.35e-101 29.6 113 7342 120 227332 Polypharmacology Molecules Target Profile
16 HNF4A and IL1B 0. 29.4 404 7342 449 227332 Polypharmacology Molecules Target Profile
17 HNF4A and GMNN 1.80e-238 29.1 267 7342 294 227332 Polypharmacology Molecules Target Profile
18 HNF4A and LHCGR 2.35e-10 248.0 8 7342 1 227332 Polypharmacology Molecules Target Profile
19 HNF4A and NR5A2 8.05e-101 187.8 78 7342 13 227332 Polypharmacology Molecules Target Profile
20 HNF4A and HSPA1A 4.62e-23 186.2 18 7342 3 227332 Polypharmacology Molecules Target Profile
21 HNF4A and NR2F2 3.96e-119 171.5 93 7342 17 227332 Polypharmacology Molecules Target Profile
22 HNF4A and NR5A1 1.57e-103 169.1 81 7342 15 227332 Polypharmacology Molecules Target Profile
23 HNF4A and NCOA2 2.37e-96 141.7 77 7342 17 227332 Polypharmacology Molecules Target Profile
24 HNF4A and NFKB1 4.51e-11 139.5 9 7342 2 227332 Polypharmacology Molecules Target Profile
25 HNF4A and NCOA3 2.78e-77 138.3 62 7342 14 227332 Polypharmacology Molecules Target Profile
26 HNF4A and ABCB6 2.85e-27 136.6 22 7342 5 227332 Polypharmacology Molecules Target Profile
27 HNF4A and NR2E3 5.57e-59 124.7 48 7342 12 227332 Polypharmacology Molecules Target Profile
28 HNF4A and IL8 1.10e-09 124.0 8 7342 2 227332 Polypharmacology Molecules Target Profile
29 HNF4A and PRNP 5.73e-81 110.2 67 7342 19 227332 Polypharmacology Molecules Target Profile
30 HNF4A and NCOA1 1.15e-24 93.2 21 7342 7 227332 Polypharmacology Molecules Target Profile
31 HNF4A and AGTR1 3.99e-21 93.1 18 7342 6 227332 Polypharmacology Molecules Target Profile
32 HNF4A and KLF5 1.71e-10 93.0 9 7342 3 227332 Polypharmacology Molecules Target Profile
33 HNF4A and TNF 2.76e-75 84.6 65 7342 24 227332 Polypharmacology Molecules Target Profile
34 HNF4A and XBP1 5.99e-22 84.3 19 7342 7 227332 Polypharmacology Molecules Target Profile
35 HNF4A and OPRK1 4.59e-17 77.6 15 7342 6 227332 Polypharmacology Molecules Target Profile
36 HNF4A and MTOR 1.55e-13 74.4 12 7342 5 227332 Polypharmacology Molecules Target Profile
37 HNF4A and NOD2 1.03e-72 70.0 65 7342 29 227332 Polypharmacology Molecules Target Profile
38 HNF4A and SELE 2.71e-22 69.0 20 7342 9 227332 Polypharmacology Molecules Target Profile
39 HNF4A and S1PR2 2.13e-14 67.2 13 7342 6 227332 Polypharmacology Molecules Target Profile
40 HNF4A and FASN 4.76e-52 66.6 47 7342 22 227332 Polypharmacology Molecules Target Profile
41 HNF4A and MMP14 8.91e-19 65.9 17 7342 8 227332 Polypharmacology Molecules Target Profile
42 HNF4A and GPR55 5.74e-21 65.5 19 7342 9 227332 Polypharmacology Molecules Target Profile
43 HNF4A and TLR9 4.68e-80 63.4 73 7342 36 227332 Polypharmacology Molecules Target Profile
44 HNF4A and S1PR1 3.92e-37 62.2 34 7342 17 227332 Polypharmacology Molecules Target Profile
45 HNF4A and NOD1 1.56e-101 59.0 94 7342 50 227332 Polypharmacology Molecules Target Profile
46 HNF4A and NPBWR1 3.97e-58 58.1 54 7342 29 227332 Polypharmacology Molecules Target Profile
47 HNF4A and GALR3 9.41e-40 57.6 37 7342 20 227332 Polypharmacology Molecules Target Profile
48 HNF4A and GLP1R 3.44e-61 57.4 57 7342 31 227332 Polypharmacology Molecules Target Profile
49 HNF4A and MCHR1 1.02e-29 54.4 28 7342 16 227332 Polypharmacology Molecules Target Profile
50 HNF4A and NPSR1 8.64e-68 54.0 64 7342 37 227332 Polypharmacology Molecules Target Profile
51 HNF4A and NLRP3 1.14e-33 52.4 32 7342 19 227332 Polypharmacology Molecules Target Profile
52 HNF4A and TP53 3.33e-30 50.1 29 7342 18 227332 Polypharmacology Molecules Target Profile
53 HNF4A and STK33 2.71e-08 49.6 8 7342 5 227332 Polypharmacology Molecules Target Profile
54 HNF4A and JAK2 3.26e-62 49.3 60 7342 38 227332 Polypharmacology Molecules Target Profile
55 HNF4A and APLNR 3.94e-38 48.0 37 7342 24 227332 Polypharmacology Molecules Target Profile
56 HNF4A and TSHR 5.36e-43 46.7 42 7342 28 227332 Polypharmacology Molecules Target Profile
57 HNF4A and TUBB 1.63e-21 46.6 21 7342 14 227332 Polypharmacology Molecules Target Profile
58 HNF4A and GPR183 3.68e-79 45.2 78 7342 54 227332 Polypharmacology Molecules Target Profile
59 HNF4A and NLRP1 1.96e-44 44.2 44 7342 31 227332 Polypharmacology Molecules Target Profile
60 HNF4A and GALR2 2.90e-42 43.6 42 7342 30 227332 Polypharmacology Molecules Target Profile
61 HNF4A and MC4R 2.06e-86 43.4 86 7342 62 227332 Polypharmacology Molecules Target Profile
62 HNF4A and RORA 6.06e-08 41.3 8 7342 6 227332 Polypharmacology Molecules Target Profile
63 HNF4A and S1PR4 2.92e-63 40.8 64 7342 49 227332 Polypharmacology Molecules Target Profile
64 HNF4A and HSP90AA1 7.97e-87 40.5 88 7342 68 227332 Polypharmacology Molecules Target Profile
65 HNF4A and KCNK3 1.37e-26 40.0 27 7342 21 227332 Polypharmacology Molecules Target Profile
66 HNF4A and HTR5A 1.56e-23 39.2 24 7342 19 227332 Polypharmacology Molecules Target Profile
67 HNF4A and MAPK1 1.66e-16 37.7 17 7342 14 227332 Polypharmacology Molecules Target Profile
68 HNF4A and CASP1 3.31e-23 37.3 24 7342 20 227332 Polypharmacology Molecules Target Profile
69 HNF4A and MMP2 1.04e-06 36.2 7 7342 6 227332 Polypharmacology Molecules Target Profile
70 HNF4A and MCOLN3 1.04e-06 36.2 7 7342 6 227332 Polypharmacology Molecules Target Profile
71 HNF4A and MLLT3 2.80e-15 35.5 16 7342 14 227332 Polypharmacology Molecules Target Profile
72 HNF4A and MDM2 1.49e-08 34.9 9 7342 8 227332 Polypharmacology Molecules Target Profile
73 HNF4A and KCNJ1 1.59e-58 34.6 62 7342 56 227332 Polypharmacology Molecules Target Profile
74 HNF4A and CHRM1 5.09e-32 34.1 34 7342 31 227332 Polypharmacology Molecules Target Profile
75 HNF4A and ATAD5 4.81e-57 31.7 62 7342 61 227332 Polypharmacology Molecules Target Profile
76 HNF4A and CHRM5 2.74e-40 31.1 44 7342 44 227332 Polypharmacology Molecules Target Profile
77 HNF4A and KCNH2 2.39e-07 31.0 8 7342 8 227332 Polypharmacology Molecules Target Profile
78 HNF4A and KCNQ1 3.04e-48 30.6 53 7342 54 227332 Polypharmacology Molecules Target Profile
79 HNF4A and RACGAP1 9.77e-40 29.8 44 7342 46 227332 Polypharmacology Molecules Target Profile
80 HNF4A and NTSR1 4.87e-23 27.9 26 7342 29 227332 Polypharmacology Molecules Target Profile
81 HNF4A and FEN1 3.54e-26 26.6 30 7342 35 227332 Polypharmacology Molecules Target Profile