Polypharmacology report

Abreviations used here:

  • kA:The number of active compounds known to target the pattern
  • KA:The total number of active compounds(IC50 < 10-6)
  • kB:The number of inactive compounds known to target the pattern
  • KB:The total number of inactive compounds(IC50 >10-6)
  • Odds Ratio: (kA/kB) / ( (KA-kA) / (KB - kB) )

Individual statistics for GLP1R in the assay 686971:

  • kA: 736
  • KA: 7342
  • kB: 5077
  • KB: 227332
  • Odds Ratio: 4.9

Table 1. Poly-pharmacological protein patterns (with GLP1R) enriched among Active molecules

# Target Duplet P-value
FDR adjusted
Odds Ratio kA KA kB KB Polypharmacology triplets View
Compounds
details
View Pattern Profile
1 GLP1R and IDH1 0. 70.4 461 7342 216 227332 Polypharmacology Molecules Target Profile
2 GLP1R and MITF 2.34e-162 40.2 165 7342 130 227332 Polypharmacology Molecules Target Profile
3 GLP1R and CFTR 3.69e-157 36.6 164 7342 142 227332 Polypharmacology Molecules Target Profile
4 GLP1R and ATXN2 9.65e-138 27.0 158 7342 185 227332 Polypharmacology Molecules Target Profile
5 GLP1R and SMAD3 5.95e-137 20.8 173 7342 264 227332 Polypharmacology Molecules Target Profile
6 GLP1R and GMNN 1.02e-205 17.9 277 7342 498 227332 Polypharmacology Molecules Target Profile
7 GLP1R and IL1B 1.10e-275 14.3 413 7342 946 227332 Polypharmacology Molecules Target Profile
8 GLP1R and OPRM1 4.12e-06 154.9 5 7342 1 227332 Polypharmacology Molecules Target Profile
9 GLP1R and USP1 8.88e-29 106.5 24 7342 7 227332 Polypharmacology Molecules Target Profile
10 GLP1R and CTNNB1 1.18e-27 82.8 24 7342 9 227332 Polypharmacology Molecules Target Profile
11 GLP1R and PLIN1 3.84e-09 82.7 8 7342 3 227332 Polypharmacology Molecules Target Profile
12 GLP1R and S100A4 8.40e-08 72.3 7 7342 3 227332 Polypharmacology Molecules Target Profile
13 GLP1R and TLR3 8.40e-08 72.3 7 7342 3 227332 Polypharmacology Molecules Target Profile
14 GLP1R and PAFAH1B3 7.61e-29 67.3 26 7342 12 227332 Polypharmacology Molecules Target Profile
15 GLP1R and TSG101 0.00029 62.0 4 7342 2 227332 Polypharmacology Molecules Target Profile
16 GLP1R and DCLRE1C 0.00029 62.0 4 7342 2 227332 Polypharmacology Molecules Target Profile
17 GLP1R and HNF4A 3.44e-61 57.4 57 7342 31 227332 Polypharmacology Molecules Target Profile
18 GLP1R and UCHL5 2.72e-22 54.3 21 7342 12 227332 Polypharmacology Molecules Target Profile
19 GLP1R and ACP1 7.49e-15 54.3 14 7342 8 227332 Polypharmacology Molecules Target Profile
20 GLP1R and JAK2 2.57e-96 53.8 91 7342 53 227332 Polypharmacology Molecules Target Profile
21 GLP1R and WRN 3.04e-26 51.8 25 7342 15 227332 Polypharmacology Molecules Target Profile
22 GLP1R and MBD2 1.83e-14 48.3 14 7342 9 227332 Polypharmacology Molecules Target Profile
23 GLP1R and GSTO1 2.35e-47 47.8 46 7342 30 227332 Polypharmacology Molecules Target Profile
24 GLP1R and RAD54L 1.30e-20 47.8 20 7342 13 227332 Polypharmacology Molecules Target Profile
25 GLP1R and TUBB 2.51e-51 47.2 50 7342 33 227332 Polypharmacology Molecules Target Profile
26 GLP1R and SUMO1 2.30e-15 46.5 15 7342 10 227332 Polypharmacology Molecules Target Profile
27 GLP1R and APOBEC3F 1.76e-25 45.7 25 7342 17 227332 Polypharmacology Molecules Target Profile
28 GLP1R and NR5A2 3.68e-79 45.2 78 7342 54 227332 Polypharmacology Molecules Target Profile
29 GLP1R and STK33 2.86e-16 45.1 16 7342 11 227332 Polypharmacology Molecules Target Profile
30 GLP1R and HKDC1 3.04e-20 44.4 20 7342 14 227332 Polypharmacology Molecules Target Profile
31 GLP1R and VDR 6.89e-46 42.1 46 7342 34 227332 Polypharmacology Molecules Target Profile
32 GLP1R and FEN1 6.25e-27 42.0 27 7342 20 227332 Polypharmacology Molecules Target Profile
33 GLP1R and PAFAH2 3.60e-27 37.8 28 7342 23 227332 Polypharmacology Molecules Target Profile
34 GLP1R and PADI4 2.49e-18 36.9 19 7342 16 227332 Polypharmacology Molecules Target Profile
35 GLP1R and POLH 1.63e-37 36.8 39 7342 33 227332 Polypharmacology Molecules Target Profile
36 GLP1R and CYP19A1 1.04e-06 36.2 7 7342 6 227332 Polypharmacology Molecules Target Profile
37 GLP1R and HIF1A 4.42e-74 35.4 78 7342 69 227332 Polypharmacology Molecules Target Profile
38 GLP1R and POLK 4.55e-14 33.2 15 7342 14 227332 Polypharmacology Molecules Target Profile
39 GLP1R and POLI 1.23e-32 33.0 35 7342 33 227332 Polypharmacology Molecules Target Profile
40 GLP1R and PAX8 1.35e-114 31.5 125 7342 125 227332 Polypharmacology Molecules Target Profile
41 GLP1R and NCOA3 3.20e-59 30.8 65 7342 66 227332 Polypharmacology Molecules Target Profile
42 GLP1R and EPAS1 4.89e-123 30.2 136 7342 142 227332 Polypharmacology Molecules Target Profile
43 GLP1R and NR5A1 9.00e-73 29.5 81 7342 86 227332 Polypharmacology Molecules Target Profile
44 GLP1R and DNMT1 8.97e-26 28.2 29 7342 32 227332 Polypharmacology Molecules Target Profile
45 GLP1R and ADRB2 1.13e-41 28.2 47 7342 52 227332 Polypharmacology Molecules Target Profile
46 GLP1R and DAGLB 4.34e-07 27.6 8 7342 9 227332 Polypharmacology Molecules Target Profile
47 GLP1R and NCOA2 1.24e-45 25.8 53 7342 64 227332 Polypharmacology Molecules Target Profile
48 GLP1R and KAT2A 0.00025 25.8 5 7342 6 227332 Polypharmacology Molecules Target Profile
49 GLP1R and OXTR 1.66e-27 25.5 32 7342 39 227332 Polypharmacology Molecules Target Profile
50 GLP1R and PRNP 1.90e-37 24.9 44 7342 55 227332 Polypharmacology Molecules Target Profile
51 GLP1R and RAD52 4.16e-38 23.1 46 7342 62 227332 Polypharmacology Molecules Target Profile
52 GLP1R and CASP1 2.57e-17 22.5 21 7342 29 227332 Polypharmacology Molecules Target Profile
53 GLP1R and PKM 9.91e-11 22.4 13 7342 18 227332 Polypharmacology Molecules Target Profile
54 GLP1R and APAF1 1.14e-37 22.4 46 7342 64 227332 Polypharmacology Molecules Target Profile
55 GLP1R and MAP4K2 1.34e-80 20.1 103 7342 161 227332 Polypharmacology Molecules Target Profile
56 GLP1R and TNFRSF10B 9.08e-94 19.6 121 7342 194 227332 Polypharmacology Molecules Target Profile
57 GLP1R and TRA@ 5.05e-14 19.3 18 7342 29 227332 Polypharmacology Molecules Target Profile
58 GLP1R and GBA 3.09e-06 19.1 8 7342 13 227332 Polypharmacology Molecules Target Profile
59 GLP1R and PRMT1 1.11e-20 18.6 27 7342 45 227332 Polypharmacology Molecules Target Profile
60 GLP1R and CXCR6 2.23e-21 18.5 28 7342 47 227332 Polypharmacology Molecules Target Profile
61 GLP1R and NPBWR1 1.01e-58 18.2 78 7342 134 227332 Polypharmacology Molecules Target Profile
62 GLP1R and PIP4K2A 6.49e-19 18.1 25 7342 43 227332 Polypharmacology Molecules Target Profile
63 GLP1R and GNAS 4.64e-06 17.7 8 7342 14 227332 Polypharmacology Molecules Target Profile
64 GLP1R and NR2F2 2.19e-62 17.6 84 7342 149 227332 Polypharmacology Molecules Target Profile
65 GLP1R and GALR3 3.71e-17 17.4 23 7342 41 227332 Polypharmacology Molecules Target Profile
66 GLP1R and NLRP1 1.45e-21 16.1 30 7342 58 227332 Polypharmacology Molecules Target Profile
67 GLP1R and ASAP1 5.15e-05 15.5 7 7342 14 227332 Polypharmacology Molecules Target Profile
68 GLP1R and POLB 3.15e-11 15.0 16 7342 33 227332 Polypharmacology Molecules Target Profile
69 GLP1R and NOD1 4.23e-55 14.9 80 7342 168 227332 Polypharmacology Molecules Target Profile
70 GLP1R and PPME1 3.49e-13 14.7 19 7342 40 227332 Polypharmacology Molecules Target Profile
71 GLP1R and ITGA4 7.31e-05 14.5 7 7342 15 227332 Polypharmacology Molecules Target Profile
72 GLP1R and TNFSF10 2.52e-20 14.1 30 7342 66 227332 Polypharmacology Molecules Target Profile
73 GLP1R and SIX1 1.88e-14 13.1 22 7342 52 227332 Polypharmacology Molecules Target Profile
74 GLP1R and PTBP1 3.84e-16 12.7 25 7342 61 227332 Polypharmacology Molecules Target Profile
75 GLP1R and KCNH2 1.24e-11 12.7 18 7342 44 227332 Polypharmacology Molecules Target Profile
76 GLP1R and MLLT3 1.05e-16 12.6 26 7342 64 227332 Polypharmacology Molecules Target Profile
77 GLP1R and RGS4 1.77e-54 12.6 86 7342 214 227332 Polypharmacology Molecules Target Profile
78 GLP1R and HTT 4.84e-48 12.5 76 7342 190 227332 Polypharmacology Molecules Target Profile
79 GLP1R and MAPK1 7.53e-09 12.1 14 7342 36 227332 Polypharmacology Molecules Target Profile
80 GLP1R and DRD3 4.31e-79 12.1 128 7342 334 227332 Polypharmacology Molecules Target Profile
81 GLP1R and NLRP3 3.01e-11 11.9 18 7342 47 227332 Polypharmacology Molecules Target Profile
82 GLP1R and COPS5 1.29e-05 11.6 9 7342 24 227332 Polypharmacology Molecules Target Profile
83 GLP1R and NFE2L2 5.64e-72 11.6 119 7342 323 227332 Polypharmacology Molecules Target Profile
84 GLP1R and SMARCA2 5.78e-17 11.3 28 7342 77 227332 Polypharmacology Molecules Target Profile
85 GLP1R and TSHR 2.43e-14 11.0 24 7342 68 227332 Polypharmacology Molecules Target Profile
86 GLP1R and MCL1 8.56e-12 10.7 20 7342 58 227332 Polypharmacology Molecules Target Profile
87 GLP1R and PSMD14 7.86e-09 10.6 15 7342 44 227332 Polypharmacology Molecules Target Profile