Polypharmacology report

Abreviations used here:

  • kA:The number of active compounds known to target the pattern
  • KA:The total number of active compounds(IC50 < 10-6)
  • kB:The number of inactive compounds known to target the pattern
  • KB:The total number of inactive compounds(IC50 >10-6)
  • Odds Ratio: (kA/kB) / ( (KA-kA) / (KB - kB) )

Individual statistics for L3MBTL1 in the assay 686971:

  • kA: 115
  • KA: 7342
  • kB: 1271
  • KB: 227332
  • Odds Ratio: 2.8

Table 1. Poly-pharmacological protein patterns (with L3MBTL1) enriched among Active molecules

# Target Duplet P-value
FDR adjusted
Odds Ratio kA KA kB KB Polypharmacology triplets View
Compounds
details
View Pattern Profile
1 L3MBTL1 and IDH1 1.22e-66 73.7 59 7342 25 227332 Polypharmacology Molecules Target Profile
2 L3MBTL1 and TNFRSF10B 5.55e-29 33.2 31 7342 29 227332 Polypharmacology Molecules Target Profile
3 L3MBTL1 and ATXN2 8.85e-28 32.2 30 7342 29 227332 Polypharmacology Molecules Target Profile
4 L3MBTL1 and SMAD3 1.63e-31 29.4 35 7342 37 227332 Polypharmacology Molecules Target Profile
5 L3MBTL1 and GMNN 3.66e-33 15.6 47 7342 94 227332 Polypharmacology Molecules Target Profile
6 L3MBTL1 and IL1B 3.55e-24 11.9 39 7342 102 227332 Polypharmacology Molecules Target Profile
7 L3MBTL1 and TDP1 8.52e-55 9.6 101 7342 331 227332 Polypharmacology Molecules Target Profile
8 L3MBTL1 and RBBP8 1.76e-24 9.5 45 7342 148 227332 Polypharmacology Molecules Target Profile
9 L3MBTL1 and SENP8 8.22e-16 8.5 31 7342 114 227332 Polypharmacology Molecules Target Profile
10 L3MBTL1 and SIX1 1.22e-21 6.9 49 7342 220 227332 Polypharmacology Molecules Target Profile
11 L3MBTL1 and PPP1CA 1.15e-10 6.9 24 7342 108 227332 Polypharmacology Molecules Target Profile
12 L3MBTL1 and XBP1 0.000101 123.9 4 7342 1 227332 Polypharmacology Molecules Target Profile
13 L3MBTL1 and CTNNB1 3.84e-09 82.7 8 7342 3 227332 Polypharmacology Molecules Target Profile
14 L3MBTL1 and S1PR3 1.37e-05 77.5 5 7342 2 227332 Polypharmacology Molecules Target Profile
15 L3MBTL1 and TNFSF10 6.99e-11 62.0 10 7342 5 227332 Polypharmacology Molecules Target Profile
16 L3MBTL1 and HTR1A 3.36e-09 46.5 9 7342 6 227332 Polypharmacology Molecules Target Profile
17 L3MBTL1 and NLRP3 7.51e-05 38.7 5 7342 4 227332 Polypharmacology Molecules Target Profile
18 L3MBTL1 and NCOA3 1.66e-16 37.7 17 7342 14 227332 Polypharmacology Molecules Target Profile
19 L3MBTL1 and S1PR4 8.81e-06 37.2 6 7342 5 227332 Polypharmacology Molecules Target Profile
20 L3MBTL1 and RORA 8.81e-06 37.2 6 7342 5 227332 Polypharmacology Molecules Target Profile
21 L3MBTL1 and GALR2 1.80e-09 34.4 10 7342 9 227332 Polypharmacology Molecules Target Profile
22 L3MBTL1 and HTR1E 2.62e-11 33.8 12 7342 11 227332 Polypharmacology Molecules Target Profile
23 L3MBTL1 and MMP14 3.85e-13 33.4 14 7342 13 227332 Polypharmacology Molecules Target Profile
24 L3MBTL1 and NOD2 6.70e-16 33.0 17 7342 16 227332 Polypharmacology Molecules Target Profile
25 L3MBTL1 and TSHR 3.44e-09 31.0 10 7342 10 227332 Polypharmacology Molecules Target Profile
26 L3MBTL1 and TNF 4.34e-12 25.5 14 7342 17 227332 Polypharmacology Molecules Target Profile
27 L3MBTL1 and NLRP1 1.57e-05 19.7 7 7342 11 227332 Polypharmacology Molecules Target Profile
28 L3MBTL1 and GSK3A 1.57e-05 19.7 7 7342 11 227332 Polypharmacology Molecules Target Profile
29 L3MBTL1 and NPY2R 9.20e-10 17.5 13 7342 23 227332 Polypharmacology Molecules Target Profile
30 L3MBTL1 and FASN 0.00018 16.9 6 7342 11 227332 Polypharmacology Molecules Target Profile
31 L3MBTL1 and PPP5C 0.0014 15.5 5 7342 10 227332 Polypharmacology Molecules Target Profile
32 L3MBTL1 and KCNQ1 6.90e-14 14.8 20 7342 42 227332 Polypharmacology Molecules Target Profile
33 L3MBTL1 and STAT3 2.73e-06 14.7 9 7342 19 227332 Polypharmacology Molecules Target Profile
34 L3MBTL1 and STAT1 2.07e-07 13.6 11 7342 25 227332 Polypharmacology Molecules Target Profile
35 L3MBTL1 and UCHL5 2.23e-09 13.6 14 7342 32 227332 Polypharmacology Molecules Target Profile
36 L3MBTL1 and HSP90AA1 2.50e-12 12.8 19 7342 46 227332 Polypharmacology Molecules Target Profile
37 L3MBTL1 and SLC5A7 9.72e-06 12.1 9 7342 23 227332 Polypharmacology Molecules Target Profile
38 L3MBTL1 and PTBP1 6.92e-07 11.8 11 7342 29 227332 Polypharmacology Molecules Target Profile
39 L3MBTL1 and SLC12A5 8.47e-08 10.9 13 7342 37 227332 Polypharmacology Molecules Target Profile
40 L3MBTL1 and HCRTR1 1.19e-09 10.0 17 7342 53 227332 Polypharmacology Molecules Target Profile
41 L3MBTL1 and ATAD5 7.39e-13 9.8 23 7342 73 227332 Polypharmacology Molecules Target Profile
42 L3MBTL1 and GNAO1 0.0024 9.3 6 7342 20 227332 Polypharmacology Molecules Target Profile
43 L3MBTL1 and MPI 1.22e-09 8.3 19 7342 71 227332 Polypharmacology Molecules Target Profile
44 L3MBTL1 and PTK2 0.00065 6.5 9 7342 43 227332 Polypharmacology Molecules Target Profile