Polypharmacology report

Abreviations used here:

  • kA:The number of active compounds known to target the pattern
  • KA:The total number of active compounds(IC50 < 10-6)
  • kB:The number of inactive compounds known to target the pattern
  • KB:The total number of inactive compounds(IC50 >10-6)
  • Odds Ratio: (kA/kB) / ( (KA-kA) / (KB - kB) )

Individual statistics for CHRM4 in the assay 686971:

  • kA: 477
  • KA: 7342
  • kB: 3840
  • KB: 227332
  • Odds Ratio: 4.0

Table 1. Poly-pharmacological protein patterns (with CHRM4) enriched among Active molecules

# Target Duplet P-value
FDR adjusted
Odds Ratio kA KA kB KB Polypharmacology triplets View
Compounds
details
View Pattern Profile
1 CHRM4 and EPAS1 4.22e-194 102.6 162 7342 50 227332 Polypharmacology Molecules Target Profile
2 CHRM4 and IDH1 0. 98.7 329 7342 108 227332 Polypharmacology Molecules Target Profile
3 CHRM4 and MITF 3.17e-228 79.1 199 7342 80 227332 Polypharmacology Molecules Target Profile
4 CHRM4 and NR5A2 5.23e-113 63.4 103 7342 51 227332 Polypharmacology Molecules Target Profile
5 CHRM4 and TNFRSF10B 3.08e-129 60.4 119 7342 62 227332 Polypharmacology Molecules Target Profile
6 CHRM4 and PAX8 1.78e-138 59.3 128 7342 68 227332 Polypharmacology Molecules Target Profile
7 CHRM4 and CCR6 1.32e-126 57.1 118 7342 65 227332 Polypharmacology Molecules Target Profile
8 CHRM4 and CXCR6 2.71e-119 51.2 114 7342 70 227332 Polypharmacology Molecules Target Profile
9 CHRM4 and JAK2 1.96e-107 50.5 103 7342 64 227332 Polypharmacology Molecules Target Profile
10 CHRM4 and ATXN2 3.11e-197 49.5 190 7342 122 227332 Polypharmacology Molecules Target Profile
11 CHRM4 and HNF4A 2.34e-105 48.5 102 7342 66 227332 Polypharmacology Molecules Target Profile
12 CHRM4 and NR5A1 8.82e-103 40.8 104 7342 80 227332 Polypharmacology Molecules Target Profile
13 CHRM4 and SMAD3 5.45e-145 38.6 149 7342 122 227332 Polypharmacology Molecules Target Profile
14 CHRM4 and CFTR 9.17e-154 36.1 161 7342 141 227332 Polypharmacology Molecules Target Profile
15 CHRM4 and NR2F2 8.35e-107 34.8 113 7342 102 227332 Polypharmacology Molecules Target Profile
16 CHRM4 and MC4R 2.21e-88 26.5 102 7342 121 227332 Polypharmacology Molecules Target Profile
17 CHRM4 and NPBWR1 6.31e-109 23.6 131 7342 175 227332 Polypharmacology Molecules Target Profile
18 CHRM4 and IL1B 2.25e-243 22.0 301 7342 440 227332 Polypharmacology Molecules Target Profile
19 CHRM4 and GMNN 2.01e-137 21.6 171 7342 251 227332 Polypharmacology Molecules Target Profile
20 CHRM4 and NFE2L2 2.85e-87 18.6 115 7342 194 227332 Polypharmacology Molecules Target Profile
21 CHRM4 and PLK1 1.44e-75 17.6 102 7342 182 227332 Polypharmacology Molecules Target Profile
22 CHRM4 and KCNQ1 1.09e-80 16.8 111 7342 207 227332 Polypharmacology Molecules Target Profile
23 CHRM4 and DRD3 4.88e-116 13.6 177 7342 413 227332 Polypharmacology Molecules Target Profile
24 CHRM4 and TDP1 1.60e-265 12.7 422 7342 1086 227332 Polypharmacology Molecules Target Profile
25 CHRM4 and HCRTR1 5.64e-75 12.1 121 7342 314 227332 Polypharmacology Molecules Target Profile
26 CHRM4 and DRD1 2.28e-68 8.8 133 7342 475 227332 Polypharmacology Molecules Target Profile
27 CHRM4 and TAAR1 1.21e-75 8.3 153 7342 580 227332 Polypharmacology Molecules Target Profile
28 CHRM4 and BCL2A1 6.27e-09 216.9 7 7342 1 227332 Polypharmacology Molecules Target Profile
29 CHRM4 and KLF5 3.72e-25 155.2 20 7342 4 227332 Polypharmacology Molecules Target Profile
30 CHRM4 and LHCGR 2.05e-17 144.8 14 7342 3 227332 Polypharmacology Molecules Target Profile
31 CHRM4 and HSPA1A 1.10e-09 124.0 8 7342 2 227332 Polypharmacology Molecules Target Profile
32 CHRM4 and NCOA1 5.12e-50 100.6 42 7342 13 227332 Polypharmacology Molecules Target Profile
33 CHRM4 and NCOA2 8.56e-42 86.2 36 7342 13 227332 Polypharmacology Molecules Target Profile
34 CHRM4 and AGTR1 8.84e-23 77.6 20 7342 8 227332 Polypharmacology Molecules Target Profile
35 CHRM4 and NCOA3 4.38e-78 74.4 69 7342 29 227332 Polypharmacology Molecules Target Profile
36 CHRM4 and HIF1A 7.32e-72 71.4 64 7342 28 227332 Polypharmacology Molecules Target Profile
37 CHRM4 and UCHL5 3.76e-23 65.2 21 7342 10 227332 Polypharmacology Molecules Target Profile
38 CHRM4 and NPSR1 1.28e-72 64.4 66 7342 32 227332 Polypharmacology Molecules Target Profile
39 CHRM4 and S1PR1 3.26e-40 53.8 38 7342 22 227332 Polypharmacology Molecules Target Profile
40 CHRM4 and GPR55 5.35e-21 51.7 20 7342 12 227332 Polypharmacology Molecules Target Profile
41 CHRM4 and ADRB2 6.58e-93 50.7 89 7342 55 227332 Polypharmacology Molecules Target Profile
42 CHRM4 and ABCB6 1.21e-16 49.6 16 7342 10 227332 Polypharmacology Molecules Target Profile
43 CHRM4 and S1PR4 1.33e-52 48.2 51 7342 33 227332 Polypharmacology Molecules Target Profile
44 CHRM4 and PRNP 9.81e-72 44.4 71 7342 50 227332 Polypharmacology Molecules Target Profile
45 CHRM4 and ALOX15B 6.06e-08 41.3 8 7342 6 227332 Polypharmacology Molecules Target Profile
46 CHRM4 and VDR 6.91e-94 40.8 95 7342 73 227332 Polypharmacology Molecules Target Profile
47 CHRM4 and TNFSF10 7.61e-13 40.3 13 7342 10 227332 Polypharmacology Molecules Target Profile
48 CHRM4 and GPR35 1.59e-12 36.7 13 7342 11 227332 Polypharmacology Molecules Target Profile
49 CHRM4 and KCNJ1 2.95e-65 36.6 68 7342 58 227332 Polypharmacology Molecules Target Profile
50 CHRM4 and XBP1 3.41e-16 35.2 17 7342 15 227332 Polypharmacology Molecules Target Profile
51 CHRM4 and APP 1.20e-53 34.2 57 7342 52 227332 Polypharmacology Molecules Target Profile
52 CHRM4 and TNF 2.17e-49 33.1 53 7342 50 227332 Polypharmacology Molecules Target Profile
53 CHRM4 and GPR183 2.69e-54 31.7 59 7342 58 227332 Polypharmacology Molecules Target Profile
54 CHRM4 and APLNR 3.26e-55 31.7 60 7342 59 227332 Polypharmacology Molecules Target Profile
55 CHRM4 and HSP90AA1 1.39e-69 31.3 76 7342 76 227332 Polypharmacology Molecules Target Profile
56 CHRM4 and NOD2 5.48e-51 30.6 56 7342 57 227332 Polypharmacology Molecules Target Profile
57 CHRM4 and TSHR 3.04e-48 30.6 53 7342 54 227332 Polypharmacology Molecules Target Profile
58 CHRM4 and RAD52 7.14e-31 30.2 34 7342 35 227332 Polypharmacology Molecules Target Profile
59 CHRM4 and NOD1 4.81e-73 29.8 81 7342 85 227332 Polypharmacology Molecules Target Profile
60 CHRM4 and TLR9 4.81e-73 29.8 81 7342 85 227332 Polypharmacology Molecules Target Profile
61 CHRM4 and NR2E3 1.07e-84 29.8 94 7342 99 227332 Polypharmacology Molecules Target Profile
62 CHRM4 and NLRP1 1.09e-29 29.3 33 7342 35 227332 Polypharmacology Molecules Target Profile
63 CHRM4 and GALR3 4.42e-51 29.2 57 7342 61 227332 Polypharmacology Molecules Target Profile
64 CHRM4 and NLRP3 5.93e-24 28.0 27 7342 30 227332 Polypharmacology Molecules Target Profile
65 CHRM4 and NTSR1 4.56e-22 24.5 26 7342 33 227332 Polypharmacology Molecules Target Profile
66 CHRM4 and HTR5A 7.58e-36 23.5 43 7342 57 227332 Polypharmacology Molecules Target Profile
67 CHRM4 and NPY2R 4.16e-38 23.1 46 7342 62 227332 Polypharmacology Molecules Target Profile
68 CHRM4 and PLA2G3 2.17e-21 22.4 26 7342 36 227332 Polypharmacology Molecules Target Profile
69 CHRM4 and KAT2A 0.00042 22.1 5 7342 7 227332 Polypharmacology Molecules Target Profile
70 CHRM4 and TP53 4.18e-17 21.7 21 7342 30 227332 Polypharmacology Molecules Target Profile
71 CHRM4 and NPY1R 2.46e-34 20.9 43 7342 64 227332 Polypharmacology Molecules Target Profile
72 CHRM4 and RACGAP1 3.58e-19 20.7 24 7342 36 227332 Polypharmacology Molecules Target Profile
73 CHRM4 and PRMT1 8.45e-65 19.3 84 7342 136 227332 Polypharmacology Molecules Target Profile
74 CHRM4 and PAFAH1B3 1.01e-14 19.0 19 7342 31 227332 Polypharmacology Molecules Target Profile
75 CHRM4 and MLLT3 3.26e-18 18.2 24 7342 41 227332 Polypharmacology Molecules Target Profile
76 CHRM4 and HTT 1.13e-57 16.5 80 7342 152 227332 Polypharmacology Molecules Target Profile
77 CHRM4 and HDAC3 0.00038 14.3 6 7342 13 227332 Polypharmacology Molecules Target Profile
78 CHRM4 and ATAD5 2.01e-40 11.4 67 7342 183 227332 Polypharmacology Molecules Target Profile
79 CHRM4 and MRGPRX1 2.42e-51 11.0 87 7342 247 227332 Polypharmacology Molecules Target Profile