Phenotypic Assay

Table P1. Single Targets Enriched Among Active molecules

  • kA:The number of active compounds known to target the gene
  • KA:The total number of active compounds(IC50 < 10-6)
  • kB:The number of inactive compounds known to target the gene
  • KB:The total number of inactive compounds(IC50 >10-6)
  • Odds Ratio: (kA/kB) / ( (KA-kA) / (KB - kB) )
# Target (Gene) P-value
FDR adjusted
Odds Ratio kA KA kB KB Polypharmacology
report
View
Compounds
details
View Target Profile
1 PPARD 1.29e-16 56.5 14 1033 11 45212 Polypharmacology Molecules Target Profile
2 KLF5 2.42e-60 53.0 54 1033 47 45212 Polypharmacology Molecules Target Profile
3 NTSR1 1.19e-31 52.5 28 1033 24 45212 Polypharmacology Molecules Target Profile
4 HSPB1 5.38e-16 47.8 14 1033 13 45212 Polypharmacology Molecules Target Profile
5 NR1H4 3.41e-21 47.0 19 1033 18 45212 Polypharmacology Molecules Target Profile
6 CTNNB1 1.14e-88 45.8 83 1033 86 45212 Polypharmacology Molecules Target Profile
7 CYP19A1 6.32e-21 37.2 20 1033 24 45212 Polypharmacology Molecules Target Profile
8 ATXN2 3.19e-85 36.8 85 1033 110 45212 Polypharmacology Molecules Target Profile
9 PAX8 2.52e-35 35.2 35 1033 45 45212 Polypharmacology Molecules Target Profile
10 IDH1 1.67e-211 29.3 234 1033 448 45212 Polypharmacology Molecules Target Profile
11 JAK2 1.70e-141 25.7 162 1033 325 45212 Polypharmacology Molecules Target Profile
12 TNF 1.08e-53 23.4 62 1033 123 45212 Polypharmacology Molecules Target Profile
13 MITF 9.14e-62 23.1 72 1033 146 45212 Polypharmacology Molecules Target Profile
14 RAD52 4.15e-12 23.0 13 1033 25 45212 Polypharmacology Molecules Target Profile
15 CFTR 1.40e-87 22.6 104 1033 223 45212 Polypharmacology Molecules Target Profile
16 PPARG 1.11e-16 21.2 19 1033 40 45212 Polypharmacology Molecules Target Profile
17 TUBB 1.01e-105 20.4 132 1033 323 45212 Polypharmacology Molecules Target Profile
18 NOD2 2.69e-54 19.2 68 1033 165 45212 Polypharmacology Molecules Target Profile
19 GMNN 9.26e-262 18.8 361 1033 1254 45212 Polypharmacology Molecules Target Profile
20 HIF1A 1.98e-73 18.3 95 1033 249 45212 Polypharmacology Molecules Target Profile
21 OPRK1 6.66e-12 18.3 14 1033 34 45212 Polypharmacology Molecules Target Profile
22 SMAD3 4.88e-62 17.7 81 1033 216 45212 Polypharmacology Molecules Target Profile
23 ALOX12 1.43e-14 17.0 18 1033 47 45212 Polypharmacology Molecules Target Profile
24 NOD1 2.16e-67 16.6 91 1033 262 45212 Polypharmacology Molecules Target Profile
25 EPAS1 6.39e-48 16.0 65 1033 189 45212 Polypharmacology Molecules Target Profile
26 STK33 1.26e-20 15.9 27 1033 76 45212 Polypharmacology Molecules Target Profile
27 AR 4.52e-23 15.3 31 1033 91 45212 Polypharmacology Molecules Target Profile
28 CXCR6 1.43e-19 15.3 26 1033 76 45212 Polypharmacology Molecules Target Profile
29 XBP1 2.08e-11 14.2 15 1033 47 45212 Polypharmacology Molecules Target Profile
30 CCR6 3.33e-22 14.1 31 1033 99 45212 Polypharmacology Molecules Target Profile
31 PAFAH1B3 7.69e-17 14.1 23 1033 73 45212 Polypharmacology Molecules Target Profile
32 NR3C1 3.85e-16 14.0 22 1033 70 45212 Polypharmacology Molecules Target Profile
33 MMP14 1.64e-61 14.0 90 1033 306 45212 Polypharmacology Molecules Target Profile
34 TLR9 5.19e-14 13.9 19 1033 61 45212 Polypharmacology Molecules Target Profile
35 CYP3A4 2.61e-19 12.8 28 1033 98 45212 Polypharmacology Molecules Target Profile
36 HTR1E 1.35e-124 12.6 200 1033 844 45212 Polypharmacology Molecules Target Profile
37 HKDC1 8.41e-11 12.6 15 1033 53 45212 Polypharmacology Molecules Target Profile
38 HTR1A 3.14e-92 12.2 148 1033 609 45212 Polypharmacology Molecules Target Profile
39 GPR55 5.18e-10 12.2 14 1033 51 45212 Polypharmacology Molecules Target Profile
40 APP 5.11e-96 11.9 157 1033 670 45212 Polypharmacology Molecules Target Profile
41 DCLRE1C 1.19e-13 11.9 20 1033 75 45212 Polypharmacology Molecules Target Profile
42 KCNQ1 1.66e-72 11.9 117 1033 481 45212 Polypharmacology Molecules Target Profile
43 APOBEC3F 3.53e-19 11.8 29 1033 110 45212 Polypharmacology Molecules Target Profile
44 BCL2A1 2.35e-07 11.6 10 1033 38 45212 Polypharmacology Molecules Target Profile
45 IL1B 1.54e-147 11.5 255 1033 1254 45212 Polypharmacology Molecules Target Profile
46 GALR2 2.37e-47 11.3 77 1033 319 45212 Polypharmacology Molecules Target Profile
47 RELA 2.23e-08 11.1 12 1033 48 45212 Polypharmacology Molecules Target Profile
48 S1PR1 6.04e-43 10.7 72 1033 315 45212 Polypharmacology Molecules Target Profile
49 APLNR 5.45e-21 10.7 34 1033 144 45212 Polypharmacology Molecules Target Profile
50 NPSR1 1.60e-55 10.5 95 1033 430 45212 Polypharmacology Molecules Target Profile
51 TLR3 4.72e-30 10.5 50 1033 217 45212 Polypharmacology Molecules Target Profile
52 NCOA3 3.56e-12 10.4 19 1033 81 45212 Polypharmacology Molecules Target Profile
53 HNF4A 5.43e-19 10.3 31 1033 135 45212 Polypharmacology Molecules Target Profile
54 ABCB1 3.99e-14 10.0 23 1033 103 45212 Polypharmacology Molecules Target Profile
55 ADAM10 1.02e-22 9.8 39 1033 181 45212 Polypharmacology Molecules Target Profile
56 MAP1LC3A 2.53e-45 9.7 81 1033 394 45212 Polypharmacology Molecules Target Profile
57 AVPR1A 7.10e-09 9.5 14 1033 65 45212 Polypharmacology Molecules Target Profile
58 BLM 4.2e-12 9.5 20 1033 94 45212 Polypharmacology Molecules Target Profile
59 S1PR3 1.71e-27 9.4 49 1033 239 45212 Polypharmacology Molecules Target Profile
60 ACP1 9.80e-09 9.3 14 1033 67 45212 Polypharmacology Molecules Target Profile
61 CASP1 3.80e-08 9.1 13 1033 63 45212 Polypharmacology Molecules Target Profile
62 ADRB2 1.13e-18 9.1 33 1033 164 45212 Polypharmacology Molecules Target Profile
63 TDP1 1.20e-244 9.0 642 1033 6947 45212 Polypharmacology Molecules Target Profile
64 NCOA1 1.95e-06 8.8 10 1033 50 45212 Polypharmacology Molecules Target Profile
65 USP1 4.33e-11 8.8 19 1033 96 45212 Polypharmacology Molecules Target Profile
66 RGS4 3.73e-43 8.8 82 1033 439 45212 Polypharmacology Molecules Target Profile
67 IDE 8.49e-19 8.8 34 1033 175 45212 Polypharmacology Molecules Target Profile
68 S1PR2 1.11e-25 8.7 48 1033 253 45212 Polypharmacology Molecules Target Profile
69 RBBP8 2.25e-15 8.4 28 1033 149 45212 Polypharmacology Molecules Target Profile
70 THRB 2.69e-07 8.4 12 1033 63 45212 Polypharmacology Molecules Target Profile
71 FEN1 4.00e-09 8.2 16 1033 87 45212 Polypharmacology Molecules Target Profile
72 PRNP 5.67e-17 8.1 32 1033 177 45212 Polypharmacology Molecules Target Profile
73 CYP1A2 1.23e-07 8.1 13 1033 71 45212 Polypharmacology Molecules Target Profile
74 MCHR1 9.08e-15 7.9 28 1033 158 45212 Polypharmacology Molecules Target Profile
75 PPME1 1.31e-17 7.9 34 1033 194 45212 Polypharmacology Molecules Target Profile
76 SIX1 1.60e-15 7.7 30 1033 174 45212 Polypharmacology Molecules Target Profile
77 DUSP1 2.57e-08 7.6 15 1033 87 45212 Polypharmacology Molecules Target Profile
78 PPP1CA 1.29e-25 7.5 53 1033 324 45212 Polypharmacology Molecules Target Profile
79 TLR4 3.07e-06 7.3 11 1033 67 45212 Polypharmacology Molecules Target Profile
80 APAF1 1.01e-32 7.2 71 1033 460 45212 Polypharmacology Molecules Target Profile
81 CDC25B 1.19e-06 7.2 12 1033 74 45212 Polypharmacology Molecules Target Profile
82 MLLT3 1.02e-05 7.1 10 1033 62 45212 Polypharmacology Molecules Target Profile
83 PPP5C 2.19e-08 7.1 16 1033 100 45212 Polypharmacology Molecules Target Profile
84 ATG4B 3.13e-13 7.1 27 1033 171 45212 Polypharmacology Molecules Target Profile
85 TP53 8.83e-46 6.9 104 1033 717 45212 Polypharmacology Molecules Target Profile
86 PLA2G1B 2.23e-10 6.9 21 1033 136 45212 Polypharmacology Molecules Target Profile
87 NR2E3 5.43e-19 6.9 41 1033 271 45212 Polypharmacology Molecules Target Profile
88 OXTR 6.40e-10 6.8 20 1033 130 45212 Polypharmacology Molecules Target Profile
89 NR5A2 1.05e-13 6.8 29 1033 192 45212 Polypharmacology Molecules Target Profile
90 VDR 8.66e-21 6.7 46 1033 311 45212 Polypharmacology Molecules Target Profile
91 DLD 2.54e-16 6.5 36 1033 248 45212 Polypharmacology Molecules Target Profile
92 SUMO1 9.47e-09 6.5 18 1033 123 45212 Polypharmacology Molecules Target Profile
93 NFE2L2 4.06e-56 6.5 137 1033 1040 45212 Polypharmacology Molecules Target Profile
94 ADAM17 4.16e-15 6.4 34 1033 241 45212 Polypharmacology Molecules Target Profile
95 ALOX15B 4.06e-08 6.2 17 1033 121 45212 Polypharmacology Molecules Target Profile
96 RAD54L 4.73e-06 6.2 12 1033 86 45212 Polypharmacology Molecules Target Profile
97 S1PR4 6.05e-14 6.1 32 1033 234 45212 Polypharmacology Molecules Target Profile
98 CDC42 3.27e-05 6.1 10 1033 72 45212 Polypharmacology Molecules Target Profile
99 NLRP3 7.27e-12 6.1 27 1033 199 45212 Polypharmacology Molecules Target Profile
100 KCNJ1 7.82e-28 6.0 69 1033 530 45212 Polypharmacology Molecules Target Profile
101 VCP 1.04e-08 6.0 19 1033 140 45212 Polypharmacology Molecules Target Profile
102 UBE2N 7.50e-08 5.9 17 1033 127 45212 Polypharmacology Molecules Target Profile
103 HTT 3.27e-51 5.9 135 1033 1122 45212 Polypharmacology Molecules Target Profile
104 WRN 1.67e-09 5.7 22 1033 171 45212 Polypharmacology Molecules Target Profile
105 KCNK9 1.48e-25 5.7 66 1033 534 45212 Polypharmacology Molecules Target Profile
106 TNFRSF10B 2.06e-19 5.7 49 1033 391 45212 Polypharmacology Molecules Target Profile
107 PADI4 3.22e-11 5.6 27 1033 214 45212 Polypharmacology Molecules Target Profile
108 NCOA2 6.59e-05 5.6 10 1033 79 45212 Polypharmacology Molecules Target Profile
109 PLA2G7 2.85e-26 5.5 70 1033 586 45212 Polypharmacology Molecules Target Profile
110 GLP1R 2.11e-22 5.5 59 1033 490 45212 Polypharmacology Molecules Target Profile
111 MAPT 2.71e-53 5.5 152 1033 1384 45212 Polypharmacology Molecules Target Profile
112 MCOLN3 6.48e-06 5.4 13 1033 106 45212 Polypharmacology Molecules Target Profile
113 GSTO1 1.58e-20 5.4 55 1033 468 45212 Polypharmacology Molecules Target Profile
114 L3MBTL1 1.76e-11 5.4 29 1033 242 45212 Polypharmacology Molecules Target Profile
115 RBBP9 9.41e-05 5.3 10 1033 83 45212 Polypharmacology Molecules Target Profile
116 NFKB1 6.21e-08 5.3 19 1033 159 45212 Polypharmacology Molecules Target Profile
117 NPY2R 1.97e-26 5.3 74 1033 654 45212 Polypharmacology Molecules Target Profile
118 GNA15 2.80e-12 5.2 32 1033 274 45212 Polypharmacology Molecules Target Profile
119 POLK 6.71e-10 5.2 25 1033 213 45212 Polypharmacology Molecules Target Profile
120 MC4R 3.58e-19 5.2 53 1033 469 45212 Polypharmacology Molecules Target Profile
121 GALR3 9.52e-08 5.1 19 1033 164 45212 Polypharmacology Molecules Target Profile
122 MAPK1 4.55e-19 5.1 53 1033 472 45212 Polypharmacology Molecules Target Profile
123 PREPL 1.28e-15 5.1 43 1033 385 45212 Polypharmacology Molecules Target Profile
124 POLH 7.98e-20 5.0 57 1033 524 45212 Polypharmacology Molecules Target Profile
125 APOBEC3G 3.17e-12 4.9 34 1033 312 45212 Polypharmacology Molecules Target Profile
126 RORA 8.01e-39 4.8 122 1033 1218 45212 Polypharmacology Molecules Target Profile
127 TAAR1 9.92e-28 4.8 85 1033 825 45212 Polypharmacology Molecules Target Profile
128 NPBWR1 3.38e-19 4.8 57 1033 543 45212 Polypharmacology Molecules Target Profile
129 NR5A1 4.48e-47 4.8 153 1033 1590 45212 Polypharmacology Molecules Target Profile
130 KCNK3 9.88e-16 4.8 46 1033 438 45212 Polypharmacology Molecules Target Profile
131 NPY1R 1.27e-24 4.7 76 1033 745 45212 Polypharmacology Molecules Target Profile
132 TNFSF10 2.92e-06 4.7 16 1033 151 45212 Polypharmacology Molecules Target Profile
133 MAP4K2 4.28e-17 4.6 53 1033 531 45212 Polypharmacology Molecules Target Profile
134 KCNH2 1.93e-10 4.5 31 1033 309 45212 Polypharmacology Molecules Target Profile
135 ALOX15 2.19e-19 4.5 62 1033 635 45212 Polypharmacology Molecules Target Profile
136 HSP90AA1 3.68e-14 4.4 45 1033 465 45212 Polypharmacology Molecules Target Profile
137 COPS5 2.85e-05 4.3 14 1033 143 45212 Polypharmacology Molecules Target Profile
138 PAFAH2 1.24e-08 4.3 26 1033 270 45212 Polypharmacology Molecules Target Profile
139 PTGER2 8.53e-16 4.3 52 1033 555 45212 Polypharmacology Molecules Target Profile
140 GPR183 4.20e-09 4.3 28 1033 294 45212 Polypharmacology Molecules Target Profile
141 GNAS 0.00012 4.2 12 1033 125 45212 Polypharmacology Molecules Target Profile
142 ALPI 0.000508 4.2 10 1033 105 45212 Polypharmacology Molecules Target Profile
143 CBX1 1.64e-06 4.2 19 1033 202 45212 Polypharmacology Molecules Target Profile
144 CACNA1H 3.48e-38 4.1 143 1033 1686 45212 Polypharmacology Molecules Target Profile
145 NR2F2 2.39e-08 4.1 26 1033 280 45212 Polypharmacology Molecules Target Profile
146 TDP2 0.00029 4.1 11 1033 118 45212 Polypharmacology Molecules Target Profile
147 HCRTR1 4.85e-23 4.1 83 1033 942 45212 Polypharmacology Molecules Target Profile
148 DNMT1 1.09e-10 4.0 36 1033 402 45212 Polypharmacology Molecules Target Profile
149 POLI 3.32e-11 3.9 39 1033 446 45212 Polypharmacology Molecules Target Profile
150 NLRP1 3.95e-08 3.9 27 1033 309 45212 Polypharmacology Molecules Target Profile
151 TARDBP 5.38e-17 3.9 63 1033 743 45212 Polypharmacology Molecules Target Profile
152 CHRM4 1.05e-13 3.9 50 1033 586 45212 Polypharmacology Molecules Target Profile
153 BAZ2B 1.88e-36 3.8 153 1033 1986 45212 Polypharmacology Molecules Target Profile
154 BAP1 4.97e-07 3.7 24 1033 288 45212 Polypharmacology Molecules Target Profile
155 POLB 7.25e-15 3.7 58 1033 714 45212 Polypharmacology Molecules Target Profile
156 HTR5A 1.04e-07 3.7 27 1033 326 45212 Polypharmacology Molecules Target Profile
157 GAPDH 6.45e-10 3.7 37 1033 454 45212 Polypharmacology Molecules Target Profile
158 MRGPRX1 4.56e-22 3.6 94 1033 1229 45212 Polypharmacology Molecules Target Profile
159 ITGA4 6.15e-07 3.5 25 1033 314 45212 Polypharmacology Molecules Target Profile
160 MPI 4.93e-09 3.4 36 1033 470 45212 Polypharmacology Molecules Target Profile
161 EIF4H 4.22e-11 3.4 46 1033 606 45212 Polypharmacology Molecules Target Profile
162 ALPPL2 1.79e-09 3.4 39 1033 519 45212 Polypharmacology Molecules Target Profile
163 SLC12A5 5.45e-14 3.3 62 1033 846 45212 Polypharmacology Molecules Target Profile
164 STAT3 5.77e-17 3.3 78 1033 1091 45212 Polypharmacology Molecules Target Profile
165 DRD3 3.97e-27 3.3 134 1033 1958 45212 Polypharmacology Molecules Target Profile
166 PIP4K2A 5.30e-07 3.3 28 1033 380 45212 Polypharmacology Molecules Target Profile
167 PTK2 1.12e-06 3.2 27 1033 372 45212 Polypharmacology Molecules Target Profile
168 BCL2L1 1.84e-08 3.2 37 1033 521 45212 Polypharmacology Molecules Target Profile
169 MCL1 3.68e-18 3.1 92 1033 1375 45212 Polypharmacology Molecules Target Profile
170 LYPLA2 0.0025 3.1 11 1033 157 45212 Polypharmacology Molecules Target Profile
171 CHRM1 5.72e-10 3.1 48 1033 710 45212 Polypharmacology Molecules Target Profile
172 WHSC1 0.0012 3.0 13 1033 189 45212 Polypharmacology Molecules Target Profile
173 PSMD14 0.00011 3.0 19 1033 281 45212 Polypharmacology Molecules Target Profile
174 PRMT1 1.36e-09 3.0 48 1033 731 45212 Polypharmacology Molecules Target Profile
175 FYN 8.82e-08 219.9 5 1033 1 45212 Polypharmacology Molecules Target Profile
176 TOP2A 2.88e-07 109.9 5 1033 2 45212 Polypharmacology Molecules Target Profile
177 TACR2 8.13e-06 87.9 4 1033 2 45212 Polypharmacology Molecules Target Profile
178 THPO 8.13e-06 87.9 4 1033 2 45212 Polypharmacology Molecules Target Profile
179 EGFR 7.22e-07 73.3 5 1033 3 45212 Polypharmacology Molecules Target Profile
180 CALM2 0.00021 65.8 3 1033 2 45212 Polypharmacology Molecules Target Profile
181 MTOR 0.00021 65.8 3 1033 2 45212 Polypharmacology Molecules Target Profile
182 CALM1 0.00021 65.8 3 1033 2 45212 Polypharmacology Molecules Target Profile
183 CALM3 0.00021 65.8 3 1033 2 45212 Polypharmacology Molecules Target Profile
184 HSPA1A 2.38e-08 44.1 7 1033 7 45212 Polypharmacology Molecules Target Profile
185 RXRA 3.53e-05 43.9 4 1033 4 45212 Polypharmacology Molecules Target Profile
186 OPRD1 0.00041 43.9 3 1033 3 45212 Polypharmacology Molecules Target Profile
187 PIM2 0.00506 43.9 2 1033 2 45212 Polypharmacology Molecules Target Profile
188 SLC22A1 0.00506 43.9 2 1033 2 45212 Polypharmacology Molecules Target Profile
189 ADRB3 0.00506 43.9 2 1033 2 45212 Polypharmacology Molecules Target Profile
190 OPRM1 6.78e-09 35.3 8 1033 10 45212 Polypharmacology Molecules Target Profile
191 AGTR1 7.16e-08 34.3 7 1033 9 45212 Polypharmacology Molecules Target Profile
192 RORC 1.25e-06 29.3 6 1033 9 45212 Polypharmacology Molecules Target Profile
193 NFKBIA 1.25e-06 29.3 6 1033 9 45212 Polypharmacology Molecules Target Profile
194 MPHOSPH8 1.37e-05 27.5 5 1033 8 45212 Polypharmacology Molecules Target Profile
195 PLIN1 0.00014 25.1 4 1033 7 45212 Polypharmacology Molecules Target Profile
196 BCL2L2 0.00014 25.1 4 1033 7 45212 Polypharmacology Molecules Target Profile
197 ADORA3 2.91e-06 24.0 6 1033 11 45212 Polypharmacology Molecules Target Profile
198 ADRA2C 4.23e-06 22.0 6 1033 12 45212 Polypharmacology Molecules Target Profile
199 HSPA5 0.0015 21.9 3 1033 6 45212 Polypharmacology Molecules Target Profile
200 SLC22A2 0.011 21.9 2 1033 4 45212 Polypharmacology Molecules Target Profile
201 SLC47A1 0.011 21.9 2 1033 4 45212 Polypharmacology Molecules Target Profile
202 GALK1 0.00029 19.5 4 1033 9 45212 Polypharmacology Molecules Target Profile
203 HTR2A 3.59e-08 18.9 9 1033 21 45212 Polypharmacology Molecules Target Profile
204 HTR6 5.91e-05 18.3 5 1033 12 45212 Polypharmacology Molecules Target Profile
205 HTR2B 3.25e-07 17.6 8 1033 20 45212 Polypharmacology Molecules Target Profile
206 ALOX5 0.015 17.5 2 1033 5 45212 Polypharmacology Molecules Target Profile
207 PIM1 0.015 17.5 2 1033 5 45212 Polypharmacology Molecules Target Profile
208 CYP3A7 7.85e-05 16.9 5 1033 13 45212 Polypharmacology Molecules Target Profile
209 SLC6A2 4.34e-07 16.8 8 1033 21 45212 Polypharmacology Molecules Target Profile
210 HTR2C 4.34e-07 16.8 8 1033 21 45212 Polypharmacology Molecules Target Profile
211 ADRA2B 0.00052 16.0 4 1033 11 45212 Polypharmacology Molecules Target Profile
212 EYA2 4.93e-06 14.7 7 1033 21 45212 Polypharmacology Molecules Target Profile
213 ADRA2A 0.00069 14.6 4 1033 12 45212 Polypharmacology Molecules Target Profile
214 MLL 0.0037 14.6 3 1033 9 45212 Polypharmacology Molecules Target Profile
215 GPR32 0.018 14.6 2 1033 6 45212 Polypharmacology Molecules Target Profile
216 CHRM2 0.018 14.6 2 1033 6 45212 Polypharmacology Molecules Target Profile
217 SIGMAR1 0.018 14.6 2 1033 6 45212 Polypharmacology Molecules Target Profile
218 DRD4 0.018 14.6 2 1033 6 45212 Polypharmacology Molecules Target Profile
219 CACNB2 0.11 14.6 1 1033 3 45212 Polypharmacology Molecules Target Profile
220 PARK2 0.11 14.6 1 1033 3 45212 Polypharmacology Molecules Target Profile
221 TBXAS1 0.11 14.6 1 1033 3 45212 Polypharmacology Molecules Target Profile
222 SMPD1 0.11 14.6 1 1033 3 45212 Polypharmacology Molecules Target Profile
223 ATP1A1 0.11 14.6 1 1033 3 45212 Polypharmacology Molecules Target Profile
224 SLC12A1 0.11 14.6 1 1033 3 45212 Polypharmacology Molecules Target Profile
225 CACNA2D1 0.11 14.6 1 1033 3 45212 Polypharmacology Molecules Target Profile
226 STAT6 0.00017 13.7 5 1033 16 45212 Polypharmacology Molecules Target Profile
227 CYP3A5 0.00021 12.9 5 1033 17 45212 Polypharmacology Molecules Target Profile
228 DAGLB 0.024 12.5 2 1033 7 45212 Polypharmacology Molecules Target Profile
229 GLA 0.0057 12.0 3 1033 11 45212 Polypharmacology Molecules Target Profile
230 S100A4 0.028 11.0 2 1033 8 45212 Polypharmacology Molecules Target Profile
231 PLEC 0.028 11.0 2 1033 8 45212 Polypharmacology Molecules Target Profile
232 CACNA1S 0.14 11.0 1 1033 4 45212 Polypharmacology Molecules Target Profile
233 CACNA1D 0.14 11.0 1 1033 4 45212 Polypharmacology Molecules Target Profile
234 MAP3K5 0.14 11.0 1 1033 4 45212 Polypharmacology Molecules Target Profile
235 PGR 0.14 11.0 1 1033 4 45212 Polypharmacology Molecules Target Profile
236 CACNA1C 0.14 11.0 1 1033 4 45212 Polypharmacology Molecules Target Profile
237 GSTM1 0.0084 10.1 3 1033 13 45212 Polypharmacology Molecules Target Profile
238 ADRA1D 0.0098 9.4 3 1033 14 45212 Polypharmacology Molecules Target Profile
239 P4HB 0.00094 8.8 5 1033 25 45212 Polypharmacology Molecules Target Profile
240 NR3C2 0.15 8.8 1 1033 5 45212 Polypharmacology Molecules Target Profile
241 PDE4A 0.15 8.8 1 1033 5 45212 Polypharmacology Molecules Target Profile
242 PPARA 0.15 8.8 1 1033 5 45212 Polypharmacology Molecules Target Profile
243 CYP2D6 7.75e-06 8.6 9 1033 46 45212 Polypharmacology Molecules Target Profile
244 HRH1 0.0037 8.4 4 1033 21 45212 Polypharmacology Molecules Target Profile
245 CHRM3 0.013 8.2 3 1033 16 45212 Polypharmacology Molecules Target Profile
246 HBB 0.013 8.2 3 1033 16 45212 Polypharmacology Molecules Target Profile
247 CYP2B7P1 0.049 8.0 2 1033 11 45212 Polypharmacology Molecules Target Profile
248 CYP2B6 0.049 8.0 2 1033 11 45212 Polypharmacology Molecules Target Profile
249 MCOLN1 4.78e-05 7.8 8 1033 45 45212 Polypharmacology Molecules Target Profile
250 BCL2L10 0.015 7.7 3 1033 17 45212 Polypharmacology Molecules Target Profile
251 HRAS 7.09e-05 7.3 8 1033 48 45212 Polypharmacology Molecules Target Profile
252 CYP2C8 0.0018 7.3 5 1033 30 45212 Polypharmacology Molecules Target Profile
253 SLC6A4 0.017 7.3 3 1033 18 45212 Polypharmacology Molecules Target Profile
254 CYP2E1 0.055 7.3 2 1033 12 45212 Polypharmacology Molecules Target Profile
255 CYP2C18 0.18 7.3 1 1033 6 45212 Polypharmacology Molecules Target Profile
256 MAOB 0.18 7.3 1 1033 6 45212 Polypharmacology Molecules Target Profile
257 HRH2 0.18 7.3 1 1033 6 45212 Polypharmacology Molecules Target Profile
258 CTBP1 0.0063 7.0 4 1033 25 45212 Polypharmacology Molecules Target Profile
259 MYC 0.063 6.7 2 1033 13 45212 Polypharmacology Molecules Target Profile
260 BCL2 0.021 6.6 3 1033 20 45212 Polypharmacology Molecules Target Profile
261 MDM2 0.0032 6.3 5 1033 35 45212 Polypharmacology Molecules Target Profile
262 PTGS1 0.0702 6.3 2 1033 14 45212 Polypharmacology Molecules Target Profile
263 HTR7 0.206 6.3 1 1033 7 45212 Polypharmacology Molecules Target Profile
264 ADRB1 0.206 6.3 1 1033 7 45212 Polypharmacology Molecules Target Profile
265 SNCA 7.69e-05 6.2 9 1033 64 45212 Polypharmacology Molecules Target Profile
266 CLK1 0.01009 6.1 4 1033 29 45212 Polypharmacology Molecules Target Profile
267 GPR35 0.087 5.5 2 1033 16 45212 Polypharmacology Molecules Target Profile
268 CYP1A1 0.087 5.5 2 1033 16 45212 Polypharmacology Molecules Target Profile
269 XIAP 0.23 5.5 1 1033 8 45212 Polypharmacology Molecules Target Profile
270 RAPGEF3 0.00603 5.4 5 1033 41 45212 Polypharmacology Molecules Target Profile
271 PRKD1 0.00603 5.4 5 1033 41 45212 Polypharmacology Molecules Target Profile
272 YWHAG 0.0011 5.3 7 1033 58 45212 Polypharmacology Molecules Target Profile
273 LYPLA1 0.00025 5.2 9 1033 77 45212 Polypharmacology Molecules Target Profile
274 CTSS 0.017 4.9 4 1033 36 45212 Polypharmacology Molecules Target Profile
275 ID4 0.102 4.9 2 1033 18 45212 Polypharmacology Molecules Target Profile
276 CA3 0.25 4.9 1 1033 9 45212 Polypharmacology Molecules Target Profile
277 CASP7 0.0041 4.8 6 1033 55 45212 Polypharmacology Molecules Target Profile
278 ASAP1 0.00202 4.7 7 1033 65 45212 Polypharmacology Molecules Target Profile
279 ATM 0.0044 4.7 6 1033 56 45212 Polypharmacology Molecules Target Profile
280 CREBBP 0.0012 4.5 8 1033 78 45212 Polypharmacology Molecules Target Profile
281 PTPN22 0.024 4.4 4 1033 40 45212 Polypharmacology Molecules Target Profile
282 CA2 0.11 4.4 2 1033 20 45212 Polypharmacology Molecules Target Profile
283 KDM4A 0.27 4.4 1 1033 10 45212 Polypharmacology Molecules Target Profile
284 CA6 0.27 4.4 1 1033 10 45212 Polypharmacology Molecules Target Profile
285 SHBG 0.27 4.4 1 1033 10 45212 Polypharmacology Molecules Target Profile
286 CASP6 0.0074 4.2 6 1033 63 45212 Polypharmacology Molecules Target Profile
287 FASN 0.0023 4.0 8 1033 87 45212 Polypharmacology Molecules Target Profile
288 NR4A1 0.017 4.0 5 1033 55 45212 Polypharmacology Molecules Target Profile
289 CA1 0.13 4.0 2 1033 22 45212 Polypharmacology Molecules Target Profile
290 RAC1 0.0016 3.9 9 1033 102 45212 Polypharmacology Molecules Target Profile
291 PLA2G3 0.0017 3.8 9 1033 103 45212 Polypharmacology Molecules Target Profile
292 CYP2A6 0.309 3.6 1 1033 12 45212 Polypharmacology Molecules Target Profile
293 MMP2 0.309 3.6 1 1033 12 45212 Polypharmacology Molecules Target Profile
294 CA5A 0.309 3.6 1 1033 12 45212 Polypharmacology Molecules Target Profile
295 CA7 0.309 3.6 1 1033 12 45212 Polypharmacology Molecules Target Profile
296 RAPGEF4 0.0081 3.6 7 1033 86 45212 Polypharmacology Molecules Target Profile
297 PTPN7 0.00907 3.5 7 1033 88 45212 Polypharmacology Molecules Target Profile
298 RCE1 0.0909 3.5 3 1033 38 45212 Polypharmacology Molecules Target Profile
299 FPR2 0.0306 3.4 5 1033 65 45212 Polypharmacology Molecules Target Profile
300 CA14 0.33 3.4 1 1033 13 45212 Polypharmacology Molecules Target Profile
301 TSG101 0.17 3.2 2 1033 27 45212 Polypharmacology Molecules Target Profile
302 PTGS2 0.34 3.1 1 1033 14 45212 Polypharmacology Molecules Target Profile
303 ADORA1 0.34 3.1 1 1033 14 45212 Polypharmacology Molecules Target Profile
304 TMPRSS15 0.34 3.1 1 1033 14 45212 Polypharmacology Molecules Target Profile
305 CA4 0.34 3.1 1 1033 14 45212 Polypharmacology Molecules Target Profile
306 LARGE 0.018 3.0 7 1033 104 45212 Polypharmacology Molecules Target Profile
307 CA12 0.36 2.9 1 1033 15 45212 Polypharmacology Molecules Target Profile
308 CTDSP1 1.41e-05 2.9 25 1033 381 45212 Polypharmacology Molecules Target Profile
309 ESR2 1.04e-09 2.9 50 1033 775 45212 Polypharmacology Molecules Target Profile
310 SLC5A7 1.27e-11 2.9 62 1033 970 45212 Polypharmacology Molecules Target Profile
311 DUSP3 0.0027 2.9 12 1033 183 45212 Polypharmacology Molecules Target Profile
312 ESR1 7.41e-18 2.8 105 1033 1731 45212 Polypharmacology Molecules Target Profile
313 CTSB 0.056 2.8 5 1033 78 45212 Polypharmacology Molecules Target Profile
314 SENP6 2.91e-10 2.8 58 1033 948 45212 Polypharmacology Molecules Target Profile
315 TRPV1 0.093 2.7 4 1033 64 45212 Polypharmacology Molecules Target Profile
316 ERG 0.37 2.7 1 1033 16 45212 Polypharmacology Molecules Target Profile
317 RXFP1 0.096 2.7 4 1033 65 45212 Polypharmacology Molecules Target Profile
318 PTPN5 0.096 2.7 4 1033 65 45212 Polypharmacology Molecules Target Profile
319 MMP13 0.14 2.7 3 1033 49 45212 Polypharmacology Molecules Target Profile
320 PABPC1 6.16e-08 2.6 47 1033 808 45212 Polypharmacology Molecules Target Profile
321 ATAD5 4.46e-20 2.6 141 1033 2577 45212 Polypharmacology Molecules Target Profile
322 CHRM5 6.67e-05 2.6 26 1033 448 45212 Polypharmacology Molecules Target Profile
323 USP2 0.14 2.6 3 1033 51 45212 Polypharmacology Molecules Target Profile
324 ADORA2A 0.39 2.6 1 1033 17 45212 Polypharmacology Molecules Target Profile
325 CA9 0.39 2.6 1 1033 17 45212 Polypharmacology Molecules Target Profile
326 SENP8 9.68e-09 2.5 57 1033 1024 45212 Polypharmacology Molecules Target Profile
327 PAFAH1B2 0.000101 2.5 26 1033 461 45212 Polypharmacology Molecules Target Profile
328 ROCK2 0.011 2.5 11 1033 194 45212 Polypharmacology Molecules Target Profile
329 SELE 0.0013 2.5 18 1033 321 45212 Polypharmacology Molecules Target Profile
330 PKM 0.0019 2.5 17 1033 305 45212 Polypharmacology Molecules Target Profile
331 AHR 3.13e-10 2.4 74 1033 1389 45212 Polypharmacology Molecules Target Profile
332 PTK2B 0.26 2.4 2 1033 36 45212 Polypharmacology Molecules Target Profile
333 MBD2 0.046 2.4 7 1033 127 45212 Polypharmacology Molecules Target Profile
334 GSK3B 0.064 2.4 6 1033 109 45212 Polypharmacology Molecules Target Profile
335 EPHB4 0.12 2.4 4 1033 73 45212 Polypharmacology Molecules Target Profile
336 TRA@ 0.096 2.4 5 1033 93 45212 Polypharmacology Molecules Target Profile
337 DRD1 6.15e-13 2.4 105 1033 2071 45212 Polypharmacology Molecules Target Profile
338 C1S 0.1009 2.3 5 1033 94 45212 Polypharmacology Molecules Target Profile
339 UCHL5 0.055 2.3 7 1033 132 45212 Polypharmacology Molecules Target Profile
340 GLS 0.14 2.3 4 1033 76 45212 Polypharmacology Molecules Target Profile
341 CYP2C9 8.47e-35 2.3 436 1033 11000 45212 Polypharmacology Molecules Target Profile
342 STAT1 3.42e-09 2.3 76 1033 1533 45212 Polypharmacology Molecules Target Profile
343 PTBP1 4.94e-10 2.3 85 1033 1726 45212 Polypharmacology Molecules Target Profile
344 CTSL1 0.0049 2.2 17 1033 337 45212 Polypharmacology Molecules Target Profile
345 TSHR 5.05e-08 2.1 75 1033 1613 45212 Polypharmacology Molecules Target Profile
346 NR1I2 0.0074 2.1 18 1033 383 45212 Polypharmacology Molecules Target Profile
347 SLC6A3 0.00079 2.0 32 1033 715 45212 Polypharmacology Molecules Target Profile
348 SENP7 9.29e-05 2.0 44 1033 989 45212 Polypharmacology Molecules Target Profile
349 DRD2 2.19e-07 2.0 81 1033 1868 45212 Polypharmacology Molecules Target Profile
350 SMARCA2 0.0047 2.0 23 1033 518 45212 Polypharmacology Molecules Target Profile
351 MAPK10 0.021 2.0 15 1033 339 45212 Polypharmacology Molecules Target Profile
352 GBA 0.13 1.9 6 1033 137 45212 Polypharmacology Molecules Target Profile
353 GFER 1.92e-07 1.9 89 1033 2119 45212 Polypharmacology Molecules Target Profile
354 ALPL 0.11 1.9 7 1033 161 45212 Polypharmacology Molecules Target Profile
355 TRHR 0.023 1.9 16 1033 373 45212 Polypharmacology Molecules Target Profile
356 DRD5 0.21 1.9 4 1033 94 45212 Polypharmacology Molecules Target Profile
357 WEE1 0.017 1.9 19 1033 453 45212 Polypharmacology Molecules Target Profile
358 GAA 0.0066 1.9 25 1033 598 45212 Polypharmacology Molecules Target Profile
359 RXFP2 0.51 1.8 1 1033 24 45212 Polypharmacology Molecules Target Profile
360 GSK3A 0.081 1.8 10 1033 241 45212 Polypharmacology Molecules Target Profile
361 HDAC3 0.24 1.8 4 1033 98 45212 Polypharmacology Molecules Target Profile
362 PLK1 3.48e-05 1.7 76 1033 1984 45212 Polypharmacology Molecules Target Profile
363 EHMT2 2.28e-09 1.7 176 1033 4822 45212 Polypharmacology Molecules Target Profile
364 NCF1 0.11 1.7 10 1033 258 45212 Polypharmacology Molecules Target Profile
365 RACGAP1 0.15 1.7 7 1033 181 45212 Polypharmacology Molecules Target Profile
366 KDM4C 0.53 1.7 1 1033 26 45212 Polypharmacology Molecules Target Profile
367 ARRB1 0.25 1.6 5 1033 134 45212 Polypharmacology Molecules Target Profile
368 AVPR1B 0.54 1.6 1 1033 27 45212 Polypharmacology Molecules Target Profile
369 CASP3 0.017 1.6 30 1033 826 45212 Polypharmacology Molecules Target Profile
370 PHOSPHO1 0.011 1.6 37 1033 1039 45212 Polypharmacology Molecules Target Profile
371 ALDH1A1 4.77e-06 1.6 149 1033 4433 45212 Polypharmacology Molecules Target Profile
372 MBNL1 0.57 1.5 1 1033 29 45212 Polypharmacology Molecules Target Profile
373 ADRBK1 0.23 1.4 9 1033 275 45212 Polypharmacology Molecules Target Profile
374 UHRF1 0.24 1.4 9 1033 277 45212 Polypharmacology Molecules Target Profile
375 FPR1 0.34 1.4 5 1033 155 45212 Polypharmacology Molecules Target Profile
376 CTSG 0.43 1.4 3 1033 93 45212 Polypharmacology Molecules Target Profile
377 ABCB6 0.33 1.4 6 1033 191 45212 Polypharmacology Molecules Target Profile
378 SMN2 0.0602 1.3 48 1033 1606 45212 Polypharmacology Molecules Target Profile
379 KPNA2 0.48 1.3 3 1033 100 45212 Polypharmacology Molecules Target Profile
380 HPGD 0.059 1.3 67 1033 2344 45212 Polypharmacology Molecules Target Profile
381 APOBEC3A 0.43 1.3 5 1033 173 45212 Polypharmacology Molecules Target Profile
382 CYP2C19 0.0012 1.2 325 1033 12149 45212 Polypharmacology Molecules Target Profile
383 EIF2AK3 0.62 1.1 2 1033 79 45212 Polypharmacology Molecules Target Profile
384 ABCG2 0.70002 1.1 1 1033 40 45212 Polypharmacology Molecules Target Profile
385 MARVELD2 0.59 1.1 4 1033 163 45212 Polypharmacology Molecules Target Profile
386 MAP3K3 0.49 1.1 16 1033 653 45212 Polypharmacology Molecules Target Profile
387 NR0B1 0.53 1.0 20 1033 839 45212 Polypharmacology Molecules Target Profile
388 INS 0.61 1.0 16 1033 701 45212 Polypharmacology Molecules Target Profile
389 RAD51 0.72 1.0 1 1033 44 45212 Polypharmacology Molecules Target Profile
390 SIRT5 0.69 1.0 2 1033 88 45212 Polypharmacology Molecules Target Profile
391 PRKACA 0.7005 1.0 2 1033 89 45212 Polypharmacology Molecules Target Profile
392 KAT2A 0.74 0.9 2 1033 97 45212 Polypharmacology Molecules Target Profile
393 KLK7 0.81 0.9 15 1033 743 45212 Polypharmacology Molecules Target Profile
394 ABCC1 0.76 0.9 5 1033 249 45212 Polypharmacology Molecules Target Profile
395 EPHX2 0.75 0.9 3 1033 150 45212 Polypharmacology Molecules Target Profile
396 GNAO1 0.88 0.8 7 1033 388 45212 Polypharmacology Molecules Target Profile
397 KLK5 0.91 0.8 9 1033 502 45212 Polypharmacology Molecules Target Profile
398 F12 0.95 0.7 5 1033 317 45212 Polypharmacology Molecules Target Profile
399 AKT1 0.99 0.7 10 1033 642 45212 Polypharmacology Molecules Target Profile
400 PLCG1 0.99 0.7 8 1033 526 45212 Polypharmacology Molecules Target Profile
401 RAB9A 0.99 0.7 26 1033 1701 45212 Polypharmacology Molecules Target Profile
402 NPC1 0.99 0.6 21 1033 1431 45212 Polypharmacology Molecules Target Profile
403 BRCA1 0.99 0.6 11 1033 811 45212 Polypharmacology Molecules Target Profile
404 F11 0.98 0.6 2 1033 158 45212 Polypharmacology Molecules Target Profile
405 PTH1R 0.96 0.5 1 1033 84 45212 Polypharmacology Molecules Target Profile
406 VCAM1 0.99 0.4 1 1033 112 45212 Polypharmacology Molecules Target Profile
407 PLCB3 0.99 0.3 1 1033 145 45212 Polypharmacology Molecules Target Profile
408 F2 0.99 0.3 1 1033 164 45212 Polypharmacology Molecules Target Profile
409 PDE4B 0.99 0.0 0 1033 6 45212 Polypharmacology Molecules Target Profile
410 PTPN11 0.99 0.0 0 1033 10 45212 Polypharmacology Molecules Target Profile
411 ADORA2B 0.99 0.0 0 1033 7 45212 Polypharmacology Molecules Target Profile
412 ACHE 0.99 0.0 0 1033 7 45212 Polypharmacology Molecules Target Profile
413 MPO 0.99 0.0 0 1033 4 45212 Polypharmacology Molecules Target Profile
414 CYP1B1 0.99 0.0 0 1033 8 45212 Polypharmacology Molecules Target Profile
415 RGS8 0.99 0.0 0 1033 8 45212 Polypharmacology Molecules Target Profile
416 ERAP1 0.99 0.0 0 1033 20 45212 Polypharmacology Molecules Target Profile
417 MAPK14 6.16e-07 0.0 4 1033 0 45212 Polypharmacology Molecules Target Profile
418 ADRA1A 0.99 0.0 0 1033 8 45212 Polypharmacology Molecules Target Profile
419 HCRTR2 0.99 0.0 0 1033 14 45212 Polypharmacology Molecules Target Profile
420 MAOA 0.99 0.0 0 1033 6 45212 Polypharmacology Molecules Target Profile
421 SCN5A 0.99 0.0 0 1033 7 45212 Polypharmacology Molecules Target Profile
422 FKBP1A 0.99 0.0 0 1033 17 45212 Polypharmacology Molecules Target Profile
423 HTR1B 0.99 0.0 0 1033 4 45212 Polypharmacology Molecules Target Profile
424 UGT1A9 0.99 0.0 0 1033 8 45212 Polypharmacology Molecules Target Profile
425 FGF22 0.99 0.0 0 1033 31 45212 Polypharmacology Molecules Target Profile
426 CGA 0.99 0.0 0 1033 9 45212 Polypharmacology Molecules Target Profile
427 RGS19 0.99 0.0 0 1033 8 45212 Polypharmacology Molecules Target Profile
428 SLC12A3 0.99 0.0 0 1033 8 45212 Polypharmacology Molecules Target Profile
429 BCHE 0.99 0.0 0 1033 4 45212 Polypharmacology Molecules Target Profile
430 GRM4 0.99 0.0 0 1033 21 45212 Polypharmacology Molecules Target Profile
431 IL8 0.99 0.0 0 1033 8 45212 Polypharmacology Molecules Target Profile
432 MMP12 0.99 0.0 0 1033 4 45212 Polypharmacology Molecules Target Profile
433 PMM2 0.99 0.0 0 1033 4 45212 Polypharmacology Molecules Target Profile
434 MEN1 0.99 0.0 0 1033 4 45212 Polypharmacology Molecules Target Profile
435 CCT2 0.99 0.0 0 1033 12 45212 Polypharmacology Molecules Target Profile
436 RGS12 0.99 0.0 0 1033 10 45212 Polypharmacology Molecules Target Profile
437 AKR1C2 0.99 0.0 0 1033 5 45212 Polypharmacology Molecules Target Profile
438 ABCC8 0.99 0.0 0 1033 4 45212 Polypharmacology Molecules Target Profile
439 HSD11B1 0.99 0.0 0 1033 5 45212 Polypharmacology Molecules Target Profile
440 ADRA1B 0.99 0.0 0 1033 5 45212 Polypharmacology Molecules Target Profile
441 NOX1 0.99 0.0 0 1033 9 45212 Polypharmacology Molecules Target Profile
442 UGT2B7 0.99 0.0 0 1033 4 45212 Polypharmacology Molecules Target Profile
443 GPER 0.99 0.0 0 1033 4 45212 Polypharmacology Molecules Target Profile
444 MMP9 0.99 0.0 0 1033 5 45212 Polypharmacology Molecules Target Profile
445 HTR1D 0.99 0.0 0 1033 5 45212 Polypharmacology Molecules Target Profile
446 RGS16 0.99 0.0 0 1033 8 45212 Polypharmacology Molecules Target Profile
447 AKR1C3 0.99 0.0 0 1033 9 45212 Polypharmacology Molecules Target Profile
448 KCNMA1 0.99 0.0 0 1033 5 45212 Polypharmacology Molecules Target Profile
449 CA13 0.99 0.0 0 1033 6 45212 Polypharmacology Molecules Target Profile
450 CA5B 0.99 0.0 0 1033 12 45212 Polypharmacology Molecules Target Profile
451 APEX1 0.99 0.0 0 1033 6 45212 Polypharmacology Molecules Target Profile
452 UGT1A3 0.99 0.0 0 1033 4 45212 Polypharmacology Molecules Target Profile