Phenotypic Assay

Table P1. Single Targets Enriched Among Active molecules

  • kA:The number of active compounds known to target the gene
  • KA:The total number of active compounds(IC50 < 10-6)
  • kB:The number of inactive compounds known to target the gene
  • KB:The total number of inactive compounds(IC50 >10-6)

  • Odds Ratio: (kA/kB) / ( (KA-kA) / (KB - kB) )
# Target (Gene) P-value
FDR adjusted		 Odds Ratio kA KA kB KB Polypharmacology
report		 View
Compounds
details		 View Target Profile
1 CTNNB1 1.24e-136 88.2 111 1090 58 45155 Polypharmacology Molecules Target Profile
2 KLF5 5.82e-66 59.0 58 1090 43 45155 Polypharmacology Molecules Target Profile
3 PPARD 1.15e-14 45.4 13 1090 12 45155 Polypharmacology Molecules Target Profile
4 NTSR1 1.06e-27 42.4 26 1090 26 45155 Polypharmacology Molecules Target Profile
5 PAX8 9.21e-41 40.8 39 1090 41 45155 Polypharmacology Molecules Target Profile
6 HSPB1 4.30e-14 38.9 13 1090 14 45155 Polypharmacology Molecules Target Profile
7 ATXN2 1.87e-89 37.8 89 1090 106 45155 Polypharmacology Molecules Target Profile
8 NR1H4 1.08e-17 35.8 17 1090 20 45155 Polypharmacology Molecules Target Profile
9 IDH1 1.29e-248 34.0 263 1090 419 45155 Polypharmacology Molecules Target Profile
10 JAK2 6.53e-181 32.5 192 1090 295 45155 Polypharmacology Molecules Target Profile
11 TUBB 4.36e-162 30.7 175 1090 280 45155 Polypharmacology Molecules Target Profile
12 CYP19A1 1.40e-17 29.1 18 1090 26 45155 Polypharmacology Molecules Target Profile
13 MITF 7.20e-67 24.3 77 1090 141 45155 Polypharmacology Molecules Target Profile
14 OPRK1 1.92e-15 23.1 17 1090 31 45155 Polypharmacology Molecules Target Profile
15 CFTR 7.10e-92 22.9 109 1090 218 45155 Polypharmacology Molecules Target Profile
16 TNF 1.22e-53 22.6 63 1090 122 45155 Polypharmacology Molecules Target Profile
17 GMNN 0. 22.1 411 1090 1204 45155 Polypharmacology Molecules Target Profile
18 RAD52 8.45e-12 21.8 13 1090 25 45155 Polypharmacology Molecules Target Profile
19 APOBEC3F 1.00e-34 19.3 43 1090 96 45155 Polypharmacology Molecules Target Profile
20 NOD2 4.93e-54 18.5 69 1090 164 45155 Polypharmacology Molecules Target Profile
21 PPARG 5.08e-15 18.5 18 1090 41 45155 Polypharmacology Molecules Target Profile
22 SMAD3 5.97e-64 17.6 84 1090 213 45155 Polypharmacology Molecules Target Profile
23 EPAS1 3.05e-51 16.4 69 1090 185 45155 Polypharmacology Molecules Target Profile
24 HIF1A 1.34e-67 16.4 92 1090 252 45155 Polypharmacology Molecules Target Profile
25 NOD1 1.52e-66 15.9 92 1090 261 45155 Polypharmacology Molecules Target Profile
26 CXCR6 3.55e-20 15.3 27 1090 75 45155 Polypharmacology Molecules Target Profile
27 TLR9 7.00e-16 15.0 21 1090 59 45155 Polypharmacology Molecules Target Profile
28 ALOX12 5.30e-13 14.9 17 1090 48 45155 Polypharmacology Molecules Target Profile
29 XBP1 3.43e-12 14.6 16 1090 46 45155 Polypharmacology Molecules Target Profile
30 CCR6 9.08e-24 14.5 33 1090 97 45155 Polypharmacology Molecules Target Profile
31 STK33 6.45e-19 14.3 26 1090 77 45155 Polypharmacology Molecules Target Profile
32 HTR1E 1.58e-146 14.0 224 1090 820 45155 Polypharmacology Molecules Target Profile
33 APP 9.74e-119 13.7 181 1090 646 45155 Polypharmacology Molecules Target Profile
34 MMP14 1.23e-60 13.4 91 1090 305 45155 Polypharmacology Molecules Target Profile
35 KCNQ1 1.09e-81 12.7 128 1090 470 45155 Polypharmacology Molecules Target Profile
36 GPR55 9.23e-11 12.6 15 1090 50 45155 Polypharmacology Molecules Target Profile
37 PAFAH1B3 2.89e-15 12.5 22 1090 74 45155 Polypharmacology Molecules Target Profile
38 HTR1A 1.30e-98 12.5 157 1090 600 45155 Polypharmacology Molecules Target Profile
39 BCL2A1 3.61e-08 12.4 11 1090 37 45155 Polypharmacology Molecules Target Profile
40 AR 4.76e-18 12.0 27 1090 95 45155 Polypharmacology Molecules Target Profile
41 S1PR1 1.36e-49 11.6 80 1090 307 45155 Polypharmacology Molecules Target Profile
42 GALR2 7.97e-50 11.4 81 1090 315 45155 Polypharmacology Molecules Target Profile
43 HKDC1 1.97e-09 10.9 14 1090 54 45155 Polypharmacology Molecules Target Profile
44 NPSR1 1.63e-59 10.8 101 1090 424 45155 Polypharmacology Molecules Target Profile
45 IL1B 1.19e-140 10.6 254 1090 1255 45155 Polypharmacology Molecules Target Profile
46 HNF4A 2.75e-20 10.6 33 1090 133 45155 Polypharmacology Molecules Target Profile
47 DCLRE1C 3.57e-12 10.5 19 1090 76 45155 Polypharmacology Molecules Target Profile
48 APLNR 2.85e-21 10.4 35 1090 143 45155 Polypharmacology Molecules Target Profile
49 NR3C1 2.03e-11 10.2 18 1090 74 45155 Polypharmacology Molecules Target Profile
50 TDP1 1.00e-281 10.0 701 1090 6888 45155 Polypharmacology Molecules Target Profile
51 TLR3 5.55e-28 9.7 49 1090 218 45155 Polypharmacology Molecules Target Profile
52 ADRB2 9.26e-21 9.5 36 1090 161 45155 Polypharmacology Molecules Target Profile
53 ADAM10 7.40e-23 9.5 40 1090 180 45155 Polypharmacology Molecules Target Profile
54 MAP1LC3A 1.57e-45 9.4 83 1090 392 45155 Polypharmacology Molecules Target Profile
55 RBBP8 1.85e-18 9.4 32 1090 145 45155 Polypharmacology Molecules Target Profile
56 RELA 3.93e-07 9.4 11 1090 49 45155 Polypharmacology Molecules Target Profile
57 RGS4 5.76e-48 9.2 89 1090 432 45155 Polypharmacology Molecules Target Profile
58 AVPR1A 1.44e-08 9.0 14 1090 65 45155 Polypharmacology Molecules Target Profile
59 ACP1 1.95e-08 8.8 14 1090 67 45155 Polypharmacology Molecules Target Profile
60 NCOA3 7.17e-10 8.6 17 1090 83 45155 Polypharmacology Molecules Target Profile
61 SIX1 2.02e-18 8.5 34 1090 170 45155 Polypharmacology Molecules Target Profile
62 CYP3A4 9.24e-12 8.4 21 1090 105 45155 Polypharmacology Molecules Target Profile
63 ABCB1 9.24e-12 8.4 21 1090 105 45155 Polypharmacology Molecules Target Profile
64 NCOA1 3.34e-06 8.4 10 1090 50 45155 Polypharmacology Molecules Target Profile
65 S1PR3 1.01e-23 8.2 46 1090 242 45155 Polypharmacology Molecules Target Profile
66 S1PR4 1.54e-21 8.0 42 1090 224 45155 Polypharmacology Molecules Target Profile
67 IDE 3.28e-17 8.0 33 1090 176 45155 Polypharmacology Molecules Target Profile
68 CASP1 5.79e-07 7.8 12 1090 64 45155 Polypharmacology Molecules Target Profile
69 USP1 8.64e-10 7.8 18 1090 97 45155 Polypharmacology Molecules Target Profile
70 S1PR2 6.72e-23 7.8 46 1090 255 45155 Polypharmacology Molecules Target Profile
71 PPME1 8.80e-18 7.7 35 1090 193 45155 Polypharmacology Molecules Target Profile
72 PPP5C 9.84e-10 7.7 18 1090 98 45155 Polypharmacology Molecules Target Profile
73 TLR4 7.63e-07 7.6 12 1090 66 45155 Polypharmacology Molecules Target Profile
74 APOBEC3G 1.51e-24 7.5 51 1090 295 45155 Polypharmacology Molecules Target Profile
75 PPP1CA 3.29e-26 7.4 55 1090 322 45155 Polypharmacology Molecules Target Profile
76 PRNP 1.81e-15 7.4 31 1090 178 45155 Polypharmacology Molecules Target Profile
77 BLM 5.45e-09 7.4 17 1090 97 45155 Polypharmacology Molecules Target Profile
78 DLD 1.21e-19 7.2 41 1090 243 45155 Polypharmacology Molecules Target Profile
79 VDR 6.19e-24 7.2 51 1090 306 45155 Polypharmacology Molecules Target Profile
80 THRB 3.66e-06 7.2 11 1090 64 45155 Polypharmacology Molecules Target Profile
81 NR2E3 1.38e-20 7.0 44 1090 268 45155 Polypharmacology Molecules Target Profile
82 CYP1A2 1.72e-06 7.0 12 1090 72 45155 Polypharmacology Molecules Target Profile
83 TP53 4.09e-46 6.8 107 1090 714 45155 Polypharmacology Molecules Target Profile
84 MLLT3 1.72e-05 6.7 10 1090 62 45155 Polypharmacology Molecules Target Profile
85 SNCA 1.94e-05 6.6 10 1090 63 45155 Polypharmacology Molecules Target Profile
86 L3MBTL1 2.99e-16 6.5 36 1090 235 45155 Polypharmacology Molecules Target Profile
87 NFE2L2 6.75e-59 6.5 144 1090 1033 45155 Polypharmacology Molecules Target Profile
88 ADAM17 4.68e-16 6.4 36 1090 239 45155 Polypharmacology Molecules Target Profile
89 NR5A2 4.18e-13 6.4 29 1090 192 45155 Polypharmacology Molecules Target Profile
90 UBE2N 5.12e-09 6.4 19 1090 125 45155 Polypharmacology Molecules Target Profile
91 ALOX15B 1.57e-08 6.3 18 1090 120 45155 Polypharmacology Molecules Target Profile
92 MCHR1 7.05e-11 6.3 24 1090 162 45155 Polypharmacology Molecules Target Profile
93 RBBP9 4.94e-06 6.2 12 1090 81 45155 Polypharmacology Molecules Target Profile
94 APAF1 3.11e-27 6.2 66 1090 465 45155 Polypharmacology Molecules Target Profile
95 HTT 7.54e-57 6.1 146 1090 1111 45155 Polypharmacology Molecules Target Profile
96 DUSP1 2.26e-06 6.1 13 1090 89 45155 Polypharmacology Molecules Target Profile
97 OXTR 9.94e-09 6.1 19 1090 131 45155 Polypharmacology Molecules Target Profile
98 GLP1R 3.47e-27 6.1 67 1090 482 45155 Polypharmacology Molecules Target Profile
99 KCNJ1 9.56e-29 6.0 72 1090 527 45155 Polypharmacology Molecules Target Profile
100 ATG4B 2.53e-10 5.8 24 1090 174 45155 Polypharmacology Molecules Target Profile
101 PLA2G1B 2.03e-08 5.8 19 1090 138 45155 Polypharmacology Molecules Target Profile
102 SUMO1 1.25e-07 5.8 17 1090 124 45155 Polypharmacology Molecules Target Profile
103 VCP 2.50e-08 5.7 19 1090 140 45155 Polypharmacology Molecules Target Profile
104 MCOLN3 2.31e-06 5.6 14 1090 105 45155 Polypharmacology Molecules Target Profile
105 TNFRSF10B 3.22e-19 5.5 50 1090 390 45155 Polypharmacology Molecules Target Profile
106 LYPLA1 7.94e-05 5.5 10 1090 76 45155 Polypharmacology Molecules Target Profile
107 WRN 4.62e-09 5.4 22 1090 171 45155 Polypharmacology Molecules Target Profile
108 NCOA2 0.000106 5.3 10 1090 79 45155 Polypharmacology Molecules Target Profile
109 KCNK9 7.67e-23 5.2 64 1090 536 45155 Polypharmacology Molecules Target Profile
110 PREPL 7.12e-17 5.2 46 1090 382 45155 Polypharmacology Molecules Target Profile
111 PADI4 5.54e-10 5.1 26 1090 215 45155 Polypharmacology Molecules Target Profile
112 NLRP3 3.56e-09 5.0 24 1090 202 45155 Polypharmacology Molecules Target Profile
113 FEN1 7.41e-05 5.0 11 1090 92 45155 Polypharmacology Molecules Target Profile
114 MC4R 7.21e-19 5.0 54 1090 468 45155 Polypharmacology Molecules Target Profile
115 FASN 0.00018 4.9 10 1090 85 45155 Polypharmacology Molecules Target Profile
116 RORA 3.38e-41 4.9 129 1090 1211 45155 Polypharmacology Molecules Target Profile
117 PLA2G7 3.74e-22 4.9 66 1090 590 45155 Polypharmacology Molecules Target Profile
118 GALR3 2.29e-07 4.9 19 1090 164 45155 Polypharmacology Molecules Target Profile
119 GNA15 5.42e-11 4.8 31 1090 275 45155 Polypharmacology Molecules Target Profile
120 GSTO1 1.69e-17 4.8 52 1090 471 45155 Polypharmacology Molecules Target Profile
121 MAPT 4.08e-44 4.7 143 1090 1393 45155 Polypharmacology Molecules Target Profile
122 RAD54L 0.00023 4.7 10 1090 88 45155 Polypharmacology Molecules Target Profile
123 POLK 9.72e-09 4.7 24 1090 214 45155 Polypharmacology Molecules Target Profile
124 KCNK3 3.42e-16 4.7 48 1090 436 45155 Polypharmacology Molecules Target Profile
125 BAP1 8.76e-11 4.7 31 1090 281 45155 Polypharmacology Molecules Target Profile
126 NR5A1 1.97e-47 4.7 158 1090 1585 45155 Polypharmacology Molecules Target Profile
127 GPR183 1.91e-10 4.5 31 1090 291 45155 Polypharmacology Molecules Target Profile
128 POLH 1.64e-17 4.5 55 1090 526 45155 Polypharmacology Molecules Target Profile
129 NPY2R 4.61e-21 4.5 68 1090 660 45155 Polypharmacology Molecules Target Profile
130 NFKB1 3.21e-06 4.4 17 1090 161 45155 Polypharmacology Molecules Target Profile
131 MAPK1 2.26e-15 4.4 49 1090 476 45155 Polypharmacology Molecules Target Profile
132 ALPI 0.00019 4.4 11 1090 104 45155 Polypharmacology Molecules Target Profile
133 NPBWR1 6.45e-17 4.3 55 1090 545 45155 Polypharmacology Molecules Target Profile
134 ALOX15 6.62e-19 4.3 63 1090 634 45155 Polypharmacology Molecules Target Profile
135 NPY1R 2.57e-21 4.3 73 1090 748 45155 Polypharmacology Molecules Target Profile
136 KCNH2 7.15e-10 4.2 31 1090 309 45155 Polypharmacology Molecules Target Profile
137 TARDBP 1.47e-20 4.2 71 1090 735 45155 Polypharmacology Molecules Target Profile
138 HCRTR1 1.61e-24 4.1 88 1090 937 45155 Polypharmacology Molecules Target Profile
139 TNFSF10 2.56e-05 4.1 15 1090 152 45155 Polypharmacology Molecules Target Profile
140 NR2F2 1.83e-08 4.1 27 1090 279 45155 Polypharmacology Molecules Target Profile
141 CACNA1H 1.45e-38 4.1 148 1090 1681 45155 Polypharmacology Molecules Target Profile
142 TAAR1 3.49e-21 4.0 77 1090 833 45155 Polypharmacology Molecules Target Profile
143 PTGER2 8.85e-15 4.0 52 1090 555 45155 Polypharmacology Molecules Target Profile
144 POLB 6.00e-18 4.0 65 1090 707 45155 Polypharmacology Molecules Target Profile
145 PAFAH2 1.44e-07 3.9 25 1090 271 45155 Polypharmacology Molecules Target Profile
146 MAP4K2 4.82e-13 3.8 48 1090 536 45155 Polypharmacology Molecules Target Profile
147 ITGA4 3.89e-08 3.8 28 1090 311 45155 Polypharmacology Molecules Target Profile
148 MPI 5.51e-10 3.6 39 1090 467 45155 Polypharmacology Molecules Target Profile
149 NLRP1 4.27e-07 3.5 26 1090 310 45155 Polypharmacology Molecules Target Profile
150 HSP90AA1 2.29e-09 3.4 38 1090 472 45155 Polypharmacology Molecules Target Profile
151 CHRM4 3.42e-11 3.4 47 1090 589 45155 Polypharmacology Molecules Target Profile
152 BAZ2B 4.91e-31 3.4 148 1090 1991 45155 Polypharmacology Molecules Target Profile
153 POLI 6.82e-09 3.4 36 1090 449 45155 Polypharmacology Molecules Target Profile
154 SLC12A5 5.17e-15 3.4 66 1090 842 45155 Polypharmacology Molecules Target Profile
155 GAPDH 9.40e-09 3.4 36 1090 455 45155 Polypharmacology Molecules Target Profile
156 MRGPRX1 1.72e-19 3.3 92 1090 1231 45155 Polypharmacology Molecules Target Profile
157 GNAS 0.0028 3.3 10 1090 127 45155 Polypharmacology Molecules Target Profile
158 CBX1 0.00017 3.3 16 1090 205 45155 Polypharmacology Molecules Target Profile
159 EIF4H 2.51e-10 3.2 46 1090 606 45155 Polypharmacology Molecules Target Profile
160 HTR5A 3.43e-06 3.2 25 1090 328 45155 Polypharmacology Molecules Target Profile
161 DNMT1 6.84e-07 3.1 30 1090 408 45155 Polypharmacology Molecules Target Profile
162 CHRM1 1.30e-10 3.1 51 1090 707 45155 Polypharmacology Molecules Target Profile
163 DRD3 2.00e-24 3.1 133 1090 1959 45155 Polypharmacology Molecules Target Profile
164 PIP4K2A 4.79e-06 3.0 27 1090 381 45155 Polypharmacology Molecules Target Profile
165 MCL1 3.46e-17 3.0 93 1090 1374 45155 Polypharmacology Molecules Target Profile
166 TOP2A 4.02e-07 104.0 5 1090 2 45155 Polypharmacology Molecules Target Profile
167 TACR2 1.07e-05 83.2 4 1090 2 45155 Polypharmacology Molecules Target Profile
168 THPO 1.07e-05 83.2 4 1090 2 45155 Polypharmacology Molecules Target Profile
169 FYN 1.07e-05 83.2 4 1090 2 45155 Polypharmacology Molecules Target Profile
170 CALM1 0.00025 62.3 3 1090 2 45155 Polypharmacology Molecules Target Profile
171 CALM3 0.00025 62.3 3 1090 2 45155 Polypharmacology Molecules Target Profile
172 MTOR 0.00025 62.3 3 1090 2 45155 Polypharmacology Molecules Target Profile
173 CALM2 0.00025 62.3 3 1090 2 45155 Polypharmacology Molecules Target Profile
174 BCL2L2 2.01e-07 50.0 6 1090 5 45155 Polypharmacology Molecules Target Profile
175 HSPA1A 3.54e-08 41.7 7 1090 7 45155 Polypharmacology Molecules Target Profile
176 RXRA 4.54e-05 41.6 4 1090 4 45155 Polypharmacology Molecules Target Profile
177 EGFR 4.54e-05 41.6 4 1090 4 45155 Polypharmacology Molecules Target Profile
178 OPRD1 0.00049 41.5 3 1090 3 45155 Polypharmacology Molecules Target Profile
179 PIM2 0.0057 41.5 2 1090 2 45155 Polypharmacology Molecules Target Profile
180 SLC22A1 0.0057 41.5 2 1090 2 45155 Polypharmacology Molecules Target Profile
181 NFKBIA 6.38e-08 36.5 7 1090 8 45155 Polypharmacology Molecules Target Profile
182 AGTR1 1.09e-07 32.4 7 1090 9 45155 Polypharmacology Molecules Target Profile
183 RORC 1.84e-06 27.8 6 1090 9 45155 Polypharmacology Molecules Target Profile
184 MAP3K5 0.0089 27.7 2 1090 3 45155 Polypharmacology Molecules Target Profile
185 OPRM1 2.80e-07 26.5 7 1090 11 45155 Polypharmacology Molecules Target Profile
186 PLIN1 0.00019 23.8 4 1090 7 45155 Polypharmacology Molecules Target Profile
187 SLC22A2 0.013 20.7 2 1090 4 45155 Polypharmacology Molecules Target Profile
188 SLC47A1 0.013 20.7 2 1090 4 45155 Polypharmacology Molecules Target Profile
189 GALK1 0.00037 18.5 4 1090 9 45155 Polypharmacology Molecules Target Profile
190 MPHOSPH8 0.00037 18.5 4 1090 9 45155 Polypharmacology Molecules Target Profile
191 PLEC 0.0024 17.8 3 1090 7 45155 Polypharmacology Molecules Target Profile
192 ADORA3 7.91e-05 17.3 5 1090 12 45155 Polypharmacology Molecules Target Profile
193 ALOX5 0.017 16.6 2 1090 5 45155 Polypharmacology Molecules Target Profile
194 PIM1 0.017 16.6 2 1090 5 45155 Polypharmacology Molecules Target Profile
195 CYP3A7 0.000106 16.0 5 1090 13 45155 Polypharmacology Molecules Target Profile
196 EYA2 7.50e-06 13.9 7 1090 21 45155 Polypharmacology Molecules Target Profile
197 MLL 0.0044 13.8 3 1090 9 45155 Polypharmacology Molecules Target Profile
198 GPR32 0.022 13.8 2 1090 6 45155 Polypharmacology Molecules Target Profile
199 SIGMAR1 0.022 13.8 2 1090 6 45155 Polypharmacology Molecules Target Profile
200 DRD4 0.022 13.8 2 1090 6 45155 Polypharmacology Molecules Target Profile
201 CHRM2 0.022 13.8 2 1090 6 45155 Polypharmacology Molecules Target Profile
202 CACNB2 0.12 13.8 1 1090 3 45155 Polypharmacology Molecules Target Profile
203 SMPD1 0.12 13.8 1 1090 3 45155 Polypharmacology Molecules Target Profile
204 SLC12A1 0.12 13.8 1 1090 3 45155 Polypharmacology Molecules Target Profile
205 ATP1A1 0.12 13.8 1 1090 3 45155 Polypharmacology Molecules Target Profile
206 ADRB3 0.12 13.8 1 1090 3 45155 Polypharmacology Molecules Target Profile
207 CACNA2D1 0.12 13.8 1 1090 3 45155 Polypharmacology Molecules Target Profile
208 TBXAS1 0.12 13.8 1 1090 3 45155 Polypharmacology Molecules Target Profile
209 PARK2 0.12 13.8 1 1090 3 45155 Polypharmacology Molecules Target Profile
210 HTR2C 9.65e-06 13.3 7 1090 22 45155 Polypharmacology Molecules Target Profile
211 HTR6 0.0011 12.8 4 1090 13 45155 Polypharmacology Molecules Target Profile
212 HTR2A 1.20e-05 12.7 7 1090 23 45155 Polypharmacology Molecules Target Profile
213 CYP3A5 0.00027 12.2 5 1090 17 45155 Polypharmacology Molecules Target Profile
214 ADRA2C 0.0014 11.9 4 1090 14 45155 Polypharmacology Molecules Target Profile
215 HSPA5 0.026 11.9 2 1090 7 45155 Polypharmacology Molecules Target Profile
216 SLC6A2 0.00011 10.9 6 1090 23 45155 Polypharmacology Molecules Target Profile
217 ADRA2B 0.0083 10.4 3 1090 12 45155 Polypharmacology Molecules Target Profile
218 CA3 0.034 10.4 2 1090 8 45155 Polypharmacology Molecules Target Profile
219 S100A4 0.034 10.4 2 1090 8 45155 Polypharmacology Molecules Target Profile
220 PGR 0.14 10.4 1 1090 4 45155 Polypharmacology Molecules Target Profile
221 CACNA1D 0.14 10.4 1 1090 4 45155 Polypharmacology Molecules Target Profile
222 CACNA1S 0.14 10.4 1 1090 4 45155 Polypharmacology Molecules Target Profile
223 CACNA1C 0.14 10.4 1 1090 4 45155 Polypharmacology Molecules Target Profile
224 STAT6 0.0024 9.8 4 1090 17 45155 Polypharmacology Molecules Target Profile
225 GSTM1 0.0098 9.6 3 1090 13 45155 Polypharmacology Molecules Target Profile
226 ADRA2A 0.0098 9.6 3 1090 13 45155 Polypharmacology Molecules Target Profile
227 CA6 0.0402 9.2 2 1090 9 45155 Polypharmacology Molecules Target Profile
228 HTR2B 0.000904 9.0 5 1090 23 45155 Polypharmacology Molecules Target Profile
229 CYP1A1 0.013 8.3 3 1090 15 45155 Polypharmacology Molecules Target Profile
230 PDE4A 0.16 8.3 1 1090 5 45155 Polypharmacology Molecules Target Profile
231 MAOA 0.16 8.3 1 1090 5 45155 Polypharmacology Molecules Target Profile
232 CA13 0.16 8.3 1 1090 5 45155 Polypharmacology Molecules Target Profile
233 PPARA 0.16 8.3 1 1090 5 45155 Polypharmacology Molecules Target Profile
234 NR3C2 0.16 8.3 1 1090 5 45155 Polypharmacology Molecules Target Profile
235 HRH1 0.0047 7.9 4 1090 21 45155 Polypharmacology Molecules Target Profile
236 CHRM3 0.015 7.8 3 1090 16 45155 Polypharmacology Molecules Target Profile
237 HBB 0.015 7.8 3 1090 16 45155 Polypharmacology Molecules Target Profile
238 CA5A 0.054 7.5 2 1090 11 45155 Polypharmacology Molecules Target Profile
239 CA7 0.054 7.5 2 1090 11 45155 Polypharmacology Molecules Target Profile
240 MMP2 0.054 7.5 2 1090 11 45155 Polypharmacology Molecules Target Profile
241 MCOLN1 7.29e-05 7.4 8 1090 45 45155 Polypharmacology Molecules Target Profile
242 BCL2L10 0.017 7.3 3 1090 17 45155 Polypharmacology Molecules Target Profile
243 GLA 0.061 6.9 2 1090 12 45155 Polypharmacology Molecules Target Profile
244 CA14 0.061 6.9 2 1090 12 45155 Polypharmacology Molecules Target Profile
245 CYP2C18 0.19 6.9 1 1090 6 45155 Polypharmacology Molecules Target Profile
246 HRH2 0.19 6.9 1 1090 6 45155 Polypharmacology Molecules Target Profile
247 CTBP1 0.0078 6.6 4 1090 25 45155 Polypharmacology Molecules Target Profile
248 P4HB 0.0088 6.4 4 1090 26 45155 Polypharmacology Molecules Target Profile
249 MYC 0.068 6.4 2 1090 13 45155 Polypharmacology Molecules Target Profile
250 CA4 0.068 6.4 2 1090 13 45155 Polypharmacology Molecules Target Profile
251 PRKD1 0.0013 6.2 6 1090 40 45155 Polypharmacology Molecules Target Profile
252 BCL2 0.025 6.2 3 1090 20 45155 Polypharmacology Molecules Target Profile
253 CYP2D6 0.000608 6.1 7 1090 48 45155 Polypharmacology Molecules Target Profile
254 MDM2 0.0042 5.9 5 1090 35 45155 Polypharmacology Molecules Target Profile
255 CA12 0.077 5.9 2 1090 14 45155 Polypharmacology Molecules Target Profile
256 HTR7 0.21 5.9 1 1090 7 45155 Polypharmacology Molecules Target Profile
257 ADRB1 0.21 5.9 1 1090 7 45155 Polypharmacology Molecules Target Profile
258 CYP1B1 0.21 5.9 1 1090 7 45155 Polypharmacology Molecules Target Profile
259 YWHAG 0.00029 5.8 8 1090 57 45155 Polypharmacology Molecules Target Profile
260 ERG 0.084 5.5 2 1090 15 45155 Polypharmacology Molecules Target Profile
261 ADRA1D 0.084 5.5 2 1090 15 45155 Polypharmacology Molecules Target Profile
262 CYP2C8 0.014 5.4 4 1090 31 45155 Polypharmacology Molecules Target Profile
263 ADORA2A 0.093 5.2 2 1090 16 45155 Polypharmacology Molecules Target Profile
264 CA9 0.093 5.2 2 1090 16 45155 Polypharmacology Molecules Target Profile
265 GPR35 0.093 5.2 2 1090 16 45155 Polypharmacology Molecules Target Profile
266 DAGLB 0.23 5.2 1 1090 8 45155 Polypharmacology Molecules Target Profile
267 XIAP 0.23 5.2 1 1090 8 45155 Polypharmacology Molecules Target Profile
268 RAPGEF3 0.0077 5.1 5 1090 41 45155 Polypharmacology Molecules Target Profile
269 HRAS 0.0037 5.0 6 1090 50 45155 Polypharmacology Molecules Target Profile
270 CDC25B 0.00039 4.9 9 1090 77 45155 Polypharmacology Molecules Target Profile
271 TSG101 0.046 4.8 3 1090 26 45155 Polypharmacology Molecules Target Profile
272 ID4 0.11 4.6 2 1090 18 45155 Polypharmacology Molecules Target Profile
273 CASP7 0.0056 4.5 6 1090 55 45155 Polypharmacology Molecules Target Profile
274 CDC42 0.0013 4.5 8 1090 74 45155 Polypharmacology Molecules Target Profile
275 ASAP1 0.0028 4.5 7 1090 65 45155 Polypharmacology Molecules Target Profile
276 CTSB 0.0014 4.4 8 1090 75 45155 Polypharmacology Molecules Target Profile
277 SLC6A4 0.11 4.4 2 1090 19 45155 Polypharmacology Molecules Target Profile
278 PTPN22 0.029 4.2 4 1090 40 45155 Polypharmacology Molecules Target Profile
279 CLK1 0.062 4.2 3 1090 30 45155 Polypharmacology Molecules Target Profile
280 CA2 0.12 4.1 2 1090 20 45155 Polypharmacology Molecules Target Profile
281 KDM4A 0.28 4.1 1 1090 10 45155 Polypharmacology Molecules Target Profile
282 CASP6 0.0097 4.0 6 1090 63 45155 Polypharmacology Molecules Target Profile
283 PTPN7 0.0033 3.8 8 1090 87 45155 Polypharmacology Molecules Target Profile
284 CA1 0.14 3.8 2 1090 22 45155 Polypharmacology Molecules Target Profile
285 CA5B 0.29 3.8 1 1090 11 45155 Polypharmacology Molecules Target Profile
286 CREBBP 0.0074 3.7 7 1090 79 45155 Polypharmacology Molecules Target Profile
287 RAC1 0.0023 3.7 9 1090 102 45155 Polypharmacology Molecules Target Profile
288 ATM 0.023 3.6 5 1090 57 45155 Polypharmacology Molecules Target Profile
289 PLA2G3 0.0024 3.6 9 1090 103 45155 Polypharmacology Molecules Target Profile
290 MMP13 0.051 3.5 4 1090 48 45155 Polypharmacology Molecules Target Profile
291 CYP2B6 0.31 3.5 1 1090 12 45155 Polypharmacology Molecules Target Profile
292 CYP2B7P1 0.31 3.5 1 1090 12 45155 Polypharmacology Molecules Target Profile
293 RAPGEF4 0.011 3.4 7 1090 86 45155 Polypharmacology Molecules Target Profile
294 CTSS 0.094 3.4 3 1090 37 45155 Polypharmacology Molecules Target Profile
295 USP2 0.057 3.3 4 1090 50 45155 Polypharmacology Molecules Target Profile
296 CYP2E1 0.34 3.2 1 1090 13 45155 Polypharmacology Molecules Target Profile
297 TDP2 0.0062 3.1 9 1090 120 45155 Polypharmacology Molecules Target Profile
298 NR4A1 0.077 3.0 4 1090 56 45155 Polypharmacology Molecules Target Profile
299 ADORA1 0.36 3.0 1 1090 14 45155 Polypharmacology Molecules Target Profile
300 PTGS2 0.36 3.0 1 1090 14 45155 Polypharmacology Molecules Target Profile
301 TMPRSS15 0.36 3.0 1 1090 14 45155 Polypharmacology Molecules Target Profile
302 SLC5A7 1.85e-12 2.9 66 1090 966 45155 Polypharmacology Molecules Target Profile
303 ESR1 3.28e-20 2.9 114 1090 1722 45155 Polypharmacology Molecules Target Profile
304 PRMT1 9.64e-10 2.9 50 1090 729 45155 Polypharmacology Molecules Target Profile
305 LYPLA2 0.00409 2.9 11 1090 157 45155 Polypharmacology Molecules Target Profile
306 ALPPL2 2.13e-07 2.9 36 1090 522 45155 Polypharmacology Molecules Target Profile
307 STAT3 3.45e-13 2.9 73 1090 1096 45155 Polypharmacology Molecules Target Profile
308 WHSC1 0.0021 2.9 13 1090 189 45155 Polypharmacology Molecules Target Profile
309 COPS5 0.0074 2.8 10 1090 147 45155 Polypharmacology Molecules Target Profile
310 BCL2L1 5.97e-07 2.8 35 1090 523 45155 Polypharmacology Molecules Target Profile
311 ROCK2 0.0023 2.8 13 1090 192 45155 Polypharmacology Molecules Target Profile
312 ESR2 2.28e-09 2.8 51 1090 774 45155 Polypharmacology Molecules Target Profile
313 PTK2 2.71e-05 2.8 25 1090 374 45155 Polypharmacology Molecules Target Profile
314 CTSG 0.0402 2.8 6 1090 90 45155 Polypharmacology Molecules Target Profile
315 PTGS1 0.37 2.8 1 1090 15 45155 Polypharmacology Molecules Target Profile
316 CTDSP1 3.63e-05 2.8 25 1090 381 45155 Polypharmacology Molecules Target Profile
317 PABPC1 1.87e-08 2.6 50 1090 805 45155 Polypharmacology Molecules Target Profile
318 CTSL1 0.00025 2.6 21 1090 333 45155 Polypharmacology Molecules Target Profile
319 PTBP1 2.99e-15 2.6 102 1090 1709 45155 Polypharmacology Molecules Target Profile
320 TRPV1 0.107 2.6 4 1090 64 45155 Polypharmacology Molecules Target Profile
321 PAFAH1B2 4.05e-05 2.6 28 1090 459 45155 Polypharmacology Molecules Target Profile
322 ATAD5 5.02e-20 2.6 146 1090 2572 45155 Polypharmacology Molecules Target Profile
323 PTPN5 0.11 2.6 4 1090 65 45155 Polypharmacology Molecules Target Profile
324 FPR2 0.11 2.5 4 1090 66 45155 Polypharmacology Molecules Target Profile
325 PSMD14 0.0016 2.5 17 1090 283 45155 Polypharmacology Molecules Target Profile
326 DUSP3 0.011 2.5 11 1090 184 45155 Polypharmacology Molecules Target Profile
327 AHR 4.55e-11 2.5 79 1090 1384 45155 Polypharmacology Molecules Target Profile
328 DRD1 3.14e-15 2.5 115 1090 2061 45155 Polypharmacology Molecules Target Profile
329 NR1I2 0.000509 2.4 22 1090 379 45155 Polypharmacology Molecules Target Profile
330 SENP6 7.95e-08 2.4 54 1090 952 45155 Polypharmacology Molecules Target Profile
331 LARGE 0.068 2.4 6 1090 105 45155 Polypharmacology Molecules Target Profile
332 MBD2 0.058 2.3 7 1090 127 45155 Polypharmacology Molecules Target Profile
333 GSK3B 0.079 2.3 6 1090 109 45155 Polypharmacology Molecules Target Profile
334 EPHB4 0.14 2.3 4 1090 73 45155 Polypharmacology Molecules Target Profile
335 CHRM5 0.00088 2.2 24 1090 450 45155 Polypharmacology Molecules Target Profile
336 SELE 0.0056 2.2 17 1090 322 45155 Polypharmacology Molecules Target Profile
337 UCHL5 0.068 2.2 7 1090 132 45155 Polypharmacology Molecules Target Profile
338 GLS 0.15 2.2 4 1090 76 45155 Polypharmacology Molecules Target Profile
339 PKM 0.0077 2.2 16 1090 306 45155 Polypharmacology Molecules Target Profile
340 STAT1 1.56e-08 2.2 77 1090 1532 45155 Polypharmacology Molecules Target Profile
341 CYP2C9 7.32e-32 2.2 446 1090 10990 45155 Polypharmacology Molecules Target Profile
342 SENP8 3.43e-06 2.1 52 1090 1029 45155 Polypharmacology Molecules Target Profile
343 TRHR 0.0044 2.1 19 1090 370 45155 Polypharmacology Molecules Target Profile
344 HDAC3 0.12 2.1 5 1090 97 45155 Polypharmacology Molecules Target Profile
345 TSHR 5.14e-08 2.1 78 1090 1610 45155 Polypharmacology Molecules Target Profile
346 GRM4 0.46 2.1 1 1090 20 45155 Polypharmacology Molecules Target Profile
347 SLC6A3 0.00101 1.9 33 1090 714 45155 Polypharmacology Molecules Target Profile
348 RAD51 0.34 1.9 2 1090 43 45155 Polypharmacology Molecules Target Profile
349 DRD2 5.39e-07 1.9 83 1090 1866 45155 Polypharmacology Molecules Target Profile
350 FPR1 0.11 1.9 7 1090 153 45155 Polypharmacology Molecules Target Profile
351 ARRB1 0.14 1.9 6 1090 133 45155 Polypharmacology Molecules Target Profile
352 SMARCA2 0.0091 1.9 23 1090 518 45155 Polypharmacology Molecules Target Profile
353 GFER 5.74e-07 1.9 91 1090 2117 45155 Polypharmacology Molecules Target Profile
354 WEE1 0.015 1.8 20 1090 452 45155 Polypharmacology Molecules Target Profile
355 ALPL 0.13 1.8 7 1090 161 45155 Polypharmacology Molecules Target Profile
356 EHMT2 2.60e-11 1.8 192 1090 4806 45155 Polypharmacology Molecules Target Profile
357 NCF1 0.078 1.8 11 1090 257 45155 Polypharmacology Molecules Target Profile
358 GAA 0.012 1.7 25 1090 598 45155 Polypharmacology Molecules Target Profile
359 C1S 0.25 1.7 4 1090 95 45155 Polypharmacology Molecules Target Profile
360 MAPK10 0.062 1.7 14 1090 340 45155 Polypharmacology Molecules Target Profile
361 PLK1 4.22e-05 1.7 79 1090 1981 45155 Polypharmacology Molecules Target Profile
362 KPNA2 0.27 1.7 4 1090 99 45155 Polypharmacology Molecules Target Profile
363 SENP7 0.0055 1.6 39 1090 994 45155 Polypharmacology Molecules Target Profile
364 KDM4C 0.55 1.6 1 1090 26 45155 Polypharmacology Molecules Target Profile
365 GSK3A 0.17 1.5 9 1090 242 45155 Polypharmacology Molecules Target Profile
366 ADRBK1 0.16 1.5 10 1090 274 45155 Polypharmacology Molecules Target Profile
367 UHRF1 0.17 1.5 10 1090 276 45155 Polypharmacology Molecules Target Profile
368 GBA 0.29 1.5 5 1090 138 45155 Polypharmacology Molecules Target Profile
369 ALDH1A1 1.66e-05 1.5 153 1090 4429 45155 Polypharmacology Molecules Target Profile
370 CASP3 0.051 1.5 29 1090 827 45155 Polypharmacology Molecules Target Profile
371 PHOSPHO1 0.035 1.4 36 1090 1040 45155 Polypharmacology Molecules Target Profile
372 MBNL1 0.6003 1.4 1 1090 29 45155 Polypharmacology Molecules Target Profile
373 FGF22 0.61 1.4 1 1090 30 45155 Polypharmacology Molecules Target Profile
374 ABCC1 0.307 1.3 8 1090 246 45155 Polypharmacology Molecules Target Profile
375 TRA@ 0.48 1.3 3 1090 95 45155 Polypharmacology Molecules Target Profile
376 DRD5 0.48 1.3 3 1090 95 45155 Polypharmacology Molecules Target Profile
377 ABCB6 0.38 1.3 6 1090 191 45155 Polypharmacology Molecules Target Profile
378 SMN2 0.087 1.3 49 1090 1605 45155 Polypharmacology Molecules Target Profile
379 HPGD 0.049 1.3 71 1090 2340 45155 Polypharmacology Molecules Target Profile
380 APOBEC3A 0.48 1.2 5 1090 173 45155 Polypharmacology Molecules Target Profile
381 INS 0.307 1.2 20 1090 697 45155 Polypharmacology Molecules Target Profile
382 CYP2C19 0.0089 1.2 332 1090 12142 45155 Polypharmacology Molecules Target Profile
383 PTK2B 0.68 1.1 1 1090 37 45155 Polypharmacology Molecules Target Profile
384 KLK5 0.49 1.1 13 1090 498 45155 Polypharmacology Molecules Target Profile
385 ABCG2 0.71 1.0 1 1090 40 45155 Polypharmacology Molecules Target Profile
386 RCE1 0.71 1.0 1 1090 40 45155 Polypharmacology Molecules Target Profile
387 MARVELD2 0.64 1.0 4 1090 163 45155 Polypharmacology Molecules Target Profile
388 MAP3K3 0.6003 1.0 16 1090 653 45155 Polypharmacology Molecules Target Profile
389 NR0B1 0.64 1.0 20 1090 839 45155 Polypharmacology Molecules Target Profile
390 SIRT5 0.71 0.9 2 1090 88 45155 Polypharmacology Molecules Target Profile
391 PRKACA 0.72 0.9 2 1090 89 45155 Polypharmacology Molecules Target Profile
392 KLK7 0.809 0.9 16 1090 742 45155 Polypharmacology Molecules Target Profile
393 KAT2A 0.78 0.9 2 1090 97 45155 Polypharmacology Molecules Target Profile
394 EPHX2 0.805 0.8 3 1090 150 45155 Polypharmacology Molecules Target Profile
395 F12 0.87 0.8 6 1090 316 45155 Polypharmacology Molecules Target Profile
396 BRCA1 0.97 0.8 15 1090 807 45155 Polypharmacology Molecules Target Profile
397 VCAM1 0.84 0.7 2 1090 111 45155 Polypharmacology Molecules Target Profile
398 GNAO1 0.92 0.7 7 1090 388 45155 Polypharmacology Molecules Target Profile
399 AKT1 0.99 0.7 11 1090 641 45155 Polypharmacology Molecules Target Profile
400 RACGAP1 0.92 0.7 3 1090 185 45155 Polypharmacology Molecules Target Profile
401 RXFP1 0.91 0.6 1 1090 68 45155 Polypharmacology Molecules Target Profile
402 NPC1 0.99 0.6 21 1090 1431 45155 Polypharmacology Molecules Target Profile
403 PLCB3 0.96 0.6 2 1090 144 45155 Polypharmacology Molecules Target Profile
404 RAB9A 0.99 0.5 22 1090 1705 45155 Polypharmacology Molecules Target Profile
405 F11 0.99 0.5 2 1090 158 45155 Polypharmacology Molecules Target Profile
406 EIF2AK3 0.95 0.5 1 1090 80 45155 Polypharmacology Molecules Target Profile
407 PTH1R 0.96 0.5 1 1090 84 45155 Polypharmacology Molecules Target Profile
408 PLCG1 0.99 0.5 6 1090 528 45155 Polypharmacology Molecules Target Profile
409 F2 0.99 0.3 1 1090 164 45155 Polypharmacology Molecules Target Profile
410 MMP12 0.99 0.0 0 1090 4 45155 Polypharmacology Molecules Target Profile
411 HTR1B 0.99 0.0 0 1090 4 45155 Polypharmacology Molecules Target Profile
412 AKR1C3 0.99 0.0 0 1090 9 45155 Polypharmacology Molecules Target Profile
413 HTR1D 0.99 0.0 0 1090 5 45155 Polypharmacology Molecules Target Profile
414 CGA 0.99 0.0 0 1090 9 45155 Polypharmacology Molecules Target Profile
415 MAPK14 8.08e-07 0.0 4 1090 0 45155 Polypharmacology Molecules Target Profile
416 PMM2 0.99 0.0 0 1090 4 45155 Polypharmacology Molecules Target Profile
417 ADRA1B 0.99 0.0 0 1090 5 45155 Polypharmacology Molecules Target Profile
418 RXFP2 0.99 0.0 0 1090 25 45155 Polypharmacology Molecules Target Profile
419 AKR1C2 0.99 0.0 0 1090 5 45155 Polypharmacology Molecules Target Profile
420 CYP2A6 0.99 0.0 0 1090 13 45155 Polypharmacology Molecules Target Profile
421 AVPR1B 0.99 0.0 0 1090 28 45155 Polypharmacology Molecules Target Profile
422 RGS8 0.99 0.0 0 1090 8 45155 Polypharmacology Molecules Target Profile
423 APEX1 0.99 0.0 0 1090 6 45155 Polypharmacology Molecules Target Profile
424 UGT1A3 0.99 0.0 0 1090 4 45155 Polypharmacology Molecules Target Profile
425 MPO 0.99 0.0 0 1090 4 45155 Polypharmacology Molecules Target Profile
426 RGS12 0.99 0.0 0 1090 10 45155 Polypharmacology Molecules Target Profile
427 PDE4B 0.99 0.0 0 1090 6 45155 Polypharmacology Molecules Target Profile
428 ABCC8 0.99 0.0 0 1090 4 45155 Polypharmacology Molecules Target Profile
429 CCT2 0.99 0.0 0 1090 12 45155 Polypharmacology Molecules Target Profile
430 PTPN11 0.99 0.0 0 1090 10 45155 Polypharmacology Molecules Target Profile
431 RGS19 0.99 0.0 0 1090 8 45155 Polypharmacology Molecules Target Profile
432 SCN5A 0.99 0.0 0 1090 7 45155 Polypharmacology Molecules Target Profile
433 MAOB 0.99 0.0 0 1090 7 45155 Polypharmacology Molecules Target Profile
434 SHBG 0.99 0.0 0 1090 11 45155 Polypharmacology Molecules Target Profile
435 NOX1 0.99 0.0 0 1090 9 45155 Polypharmacology Molecules Target Profile
436 UGT1A9 0.99 0.0 0 1090 8 45155 Polypharmacology Molecules Target Profile
437 ACHE 0.99 0.0 0 1090 7 45155 Polypharmacology Molecules Target Profile
438 ERAP1 0.99 0.0 0 1090 20 45155 Polypharmacology Molecules Target Profile
439 MEN1 0.99 0.0 0 1090 4 45155 Polypharmacology Molecules Target Profile
440 RGS16 0.99 0.0 0 1090 8 45155 Polypharmacology Molecules Target Profile
441 HSD11B1 0.99 0.0 0 1090 5 45155 Polypharmacology Molecules Target Profile
442 GPER 0.99 0.0 0 1090 4 45155 Polypharmacology Molecules Target Profile
443 UGT2B7 0.99 0.0 0 1090 4 45155 Polypharmacology Molecules Target Profile
444 BCHE 0.99 0.0 0 1090 4 45155 Polypharmacology Molecules Target Profile
445 ADORA2B 0.99 0.0 0 1090 7 45155 Polypharmacology Molecules Target Profile
446 MMP9 0.99 0.0 0 1090 5 45155 Polypharmacology Molecules Target Profile
447 ADRA1A 0.99 0.0 0 1090 8 45155 Polypharmacology Molecules Target Profile
448 KCNMA1 0.99 0.0 0 1090 5 45155 Polypharmacology Molecules Target Profile
449 SLC12A3 0.99 0.0 0 1090 8 45155 Polypharmacology Molecules Target Profile
450 IL8 0.99 0.0 0 1090 8 45155 Polypharmacology Molecules Target Profile
451 HCRTR2 0.99 0.0 0 1090 14 45155 Polypharmacology Molecules Target Profile
452 FKBP1A 0.99 0.0 0 1090 17 45155 Polypharmacology Molecules Target Profile